| LASS2／TMSG-1基因与肿瘤转移关系的研究进展 |
| |
| 引用本文： | 左华楚,李秀霞,徐晓艳.LASS2／TMSG-1基因与肿瘤转移关系的研究进展[J].国际病理科学与临床杂志,2014(3):280-285. |
| |
| 作者姓名： | 左华楚 李秀霞 徐晓艳 |
| |
| 作者单位： | [1]内蒙古医科大学研究生院,呼和浩特010059 [2]内蒙古医科大学第一附属医院病理科,呼和浩特010059 [3]内蒙古医科大学基础医学院病理学教研室,呼和浩特010059 |
| |
| 基金项目： | 国家自然科学基金（81201854）. |
| |
| 摘 要： | 人源性长寿保障基因2（homo sapiens longevity assurance homologue 2，LASS2）是一个与酵母长寿保障基因l（10ngevity assurance gene1，LAG1）高度同源的人类基因，又被称为肿瘤转移抑制相关基因1（tumor metastasis suppressor gene-1，TMSG-1）。目前研究发现LASS2／TMSG-1与神经酰胺合成密切相关，同时其与V-ATPase质子泵的相互作用被认为是抑制肿瘤转移的机制之一，多种肿瘤的转移都与此基因的表达相关。
|
| 关 键 词： | LASS2 TMSG-1 神经酰胺 V-ATPase质子泵 肿瘤转移 |
LASS2/TMSG-1 gene and tumor metastasis |
| |
| ZUO Huachu,LI Xiuxia XU Xiaoyan.LASS2/TMSG-1 gene and tumor metastasis[J].Journal of International Pathology and Clinical Medicine,2014(3):280-285. |
| |
| Authors: | ZUO Huachu LI Xiuxia XU Xiaoyan |
| |
| Institution: | 1. Graduate School; 2. Department of Pathology, First Affiliated Hospital; 3. Department of Pathology Teaching and Researchj Basic Medical College, Inner Mongolia Medical University, Hohehot O1005 9, China) |
| |
| Abstract: | The homo sapiens longevity assurance homologue 2 （LASS2） has a highly homologous with yeast longevity assurance gene 1 （LAG1）, which was also known as tumor metastasis suppressor gene 1 （TMSG1）. The LASS2 / TMSG-1 is closely related to the ceramide synthesis and its interaction with V-ATPase proton pump is considered to be one of the mechanisms for tumor metastasis. Avariety of tumor metastasis is associated with the expression of this gene. |
| |
| Keywords: | LASS2/TMSG- 1 ceramide V-ATPase proton pump tumor metastasis |
| 本文献已被 维普 等数据库收录！ |
