Matters of size: Roles of hyaluronan in CNS aging and disease |
| |
| Institution: | 1. Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA;2. Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA;3. Center for Neurotherapeutics Discovery, University of Rochester Medical Center, Rochester, NY, USA;4. Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA;1. Division of Geriatrics, Department of Medicine, Centre hospitalier de l’Université de Montréal, Canada;2. Centre de recherche du Centre hospitalier de l’Université de Montréal, Canada;3. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada;4. Department of Internal Medicine and Critical Care Medicine, Hôpital Maisonneuve-Rosemont, Montreal, Canada;5. Departments of Neurosciences & Social and Preventative Medicine, Université de Montréal, Canada;6. Department of Medicine, McGill University, Canada;7. Neuroepidemiology Research Unit, Research Institute of the McGill University Health Centre, Canada;3. Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006;4. Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany;5. Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239;6. Department of Neurology and Radiation Medicine, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239;1. Department of Biology, University of Rochester, Rochester, NY 14627, USA |
| |
| Abstract: | Involvement of extracellular matrix (ECM) components in aging and age-related neurodegeneration is not well understood. The role of hyaluronan (HA), a major extracellular matrix glycosaminoglycan, in malignancy and inflammation is gaining new understanding. In particular, the differential biological effects of high molecular weight (HMW-HA) and low molecular weight hyaluronan (LMW-HA), and the mechanism behind such differences are being uncovered. Tightly regulated in the brain, HA can have diverse effects on cellular development, growth and degeneration. In this review, we summarize the homeostasis and signaling of HA in healthy tissue, discuss its distribution and ontogeny in the central nervous system (CNS), summarize evidence for its involvement in age-related neurodegeneration and Alzheimer Disease (AD), and assess the potential of HA as a therapeutic target in the CNS. |
| |
| Keywords: | Hyaluronic acid Hyaluronan HA Aging CNS aging Neurodegeneration HA therapeutics |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
