| 稳定黏附的白细胞与血液流动的耦合作用 |
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| 引用本文： | 刘肖珩 黄华 陈槐卿. 稳定黏附的白细胞与血液流动的耦合作用[J]. 生物医学工程学杂志, 2005, 22(5): 956-960,994 |
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| 作者姓名： | 刘肖珩 黄华 陈槐卿 |
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| 作者单位： | 四川大学华西医院心血管疾病研究室，四川大学医学信息工程系，四川大学华西医院心血管疾病研究室 成都610041四川大学华西医学中心生物医学工程研究室，成都610041，成都610041，成都610041四川大学华西医学中心生物医学工程研究室，成都610041 |
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| 基金项目： | 国家自然科学基金资助项目(10102012) |
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| 摘 要： | 提出了血液流动与牢固黏附的白细胞之间发生耦合作用的理论模型,根据计算流体动力学方法推导血流作用下白细胞的变形指数、表面应力、压力分布。在此基础上,用激光多谱勒测速法对上述模型进行实验研究。结果表明,白细胞的变形随初始接触角、血流雷诺数的增大而增大;同时,血流引起细胞表面的应力和压力重新分配,但最大剪应力总是位于细胞表面的顶点。由此推测,细胞表面应力分布的不均一可能对细胞的形态与功能变化有重要影响。
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| 关 键 词： | 白细胞 剪应力 耦合 计算流体动力学 |
| 收稿时间： | 2005-03-01 |
| 修稿时间： | 2005-03-01 |
Coupling between Adherent Leukocytes and Blood Flow |
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| Liu Xiaoheng, Huang Hua, Chen Huaiqing. Coupling between Adherent Leukocytes and Blood Flow[J]. Journal of biomedical engineering, 2005, 22(5): 956-960,994 |
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| Authors: | Liu Xiaoheng Huang Hua Chen Huaiqing |
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| Affiliation: | 1.Laboratory of Cardiovascular Diseases, West China Hospital of Sichuan University, Chengdu 610041, China; 2.Institute of Biomedical Engineering, Center of West China Medical Sciences, Sichuan University, Chengdu 610041, China; 3.Biomedical Information Engineering Department, Sichuan University, Chengdu 610065, China |
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| Abstract: | A theoretical model was developed to simulate the coupling between the adhered leukocyte and blood flow. Methods of computational fluid dynamics (CFD) were introduced to analyze the distributions of the shear stress and the pressure on the cell surface. Meanwhile, the hemodynamical parameters were measured with laser Doppler velocimetry. The results showed that the deformation index of the leukocyte was increased with initial contact angle and Reynolds number. The blood flow induced the redistributions of the shear stress and pressure on the surface of the cell, but the maximum shear stress was on the top point of the cell. It suggests that the non-uniform distribution of shear stress on the cell surface may play a particular role in the change of cell shape and functions. |
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| Keywords: | Leukocyte Shear stress Coupling Computational fluid dynamics(CFD) |
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