神经营养因子信号转导与神经细胞凋亡的分子机制

细胞凋亡(Apoptosis)是一种程序化的细胞死亡过程,其中神经细胞的凋亡对胚胎期神经系统的生长、发育、分化、成熟及生后各种原因所致的脑损伤,神经退行性疾病的发生都起着至关重要的作用。神经营养因子(Neurotrophins,NTS)通过其与相应靶细胞膜受体的活化而引发相关信使分子的级联激活而减缓神经细胞凋亡、促进神经细胞的存活,发挥其生物学功能。对NTS家族信号转导与神经细胞凋亡的分子机制的认识有助于早期干预和治疗各种原因所致神经发育残障,脑损伤及神经退性行疾病。

The Molecular Mechanism of Signal transduction of Neurotrophins and Apoptosis of Neurocyte

Apoptosis is a programmed process of cellular death.The neurocyte apoptosis plays an important role in the growth,development,differentiation and maturity of nerve system during the embryonic period,in the brain damage caused by various reasons,and in the occurrence of nerve degenerative diseases.Neurotrophins(NTS) can initiate the cascade activation of related messenger molecules through the activation of corrersponding target cell membrane receptors,and thus delay the apoptosis of neurocytes,facilitate its survival,and bring its biological function into full play.The research of the molecular mechanism of family signal transduction of NTS and apoptosis of neurocytes will assist in the early intervention and treatment of nerve developmental handicap,brain damage and nerve degenerative diseases with different causes.