生物可降解载药纤维的制备、特征表征及释药特性的研究

为了研发一种可供脂溶性药物上载的长效释放植入生物可降解纤维载体,采用有机相分离法制备左旋聚乳酸(PLLA)纤维,扫描电镜(SEM)观察结构,差示扫描热分析(DSC)以及红外光谱分析(FTIR)分析药物载体状态,高效液相(HPLC)方法测定载药纤维的载药量,紫外分光光度法(UV)测定药物释放情况.结果表明制备出了成形性良好的空白PLLA纤维及载药纤维,药物包合入纤维中;药物与载体的结合形式为微晶分散与非晶态分散相结合,该纤维制剂在体外可以长效可调地释放.有机相分离法可以用来成功制备作为缓释植入药物载体的微米级别的左旋聚乳酸载药(PLLA)纤维.

Fabrication, Characterization and Drug Release Characteristics of Drug Loaded Poly (L-lactic acid) Fiber

To develop a long-term released and implantable biodegradable fiber carrier for hydrophobic drug incorporation, fibers were fabricated by organic phase separation method. The structure of the fiber was observed by scanning electron microscopy and the state of the drug dispersed in the polymer was measured by differential scanning colorimetry (DSC) and Fouvier transform infrared spectroscopy (FTIR). The drug loading content and release profiles were determined by high performance liquid chromatography (HPLC) and ultra-violet spectrophotometry, respectively. Blank and drug loaded fibers were successfully fabricated and the drug was entirely encapsulated into the fiber. The drug was dispersed in the polymer with minicrystal and noncrystal form. The drug release profile was long-term sustained and could be regulated. The PLLA fibers in micrometer range successfully fabricated by organic phase separation method could be taken as sustained release and implantable drug carrier.