| 烧伤大鼠粒细胞与内皮细胞粘附力学特性的研究 |
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| 引用本文： | 吴泽志,李志清,龙勉,罗向东,宋关斌,王红兵,吴云鹏.烧伤大鼠粒细胞与内皮细胞粘附力学特性的研究[J].生物医学工程学杂志,1996(3). |
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| 作者姓名： | 吴泽志 李志清 龙勉 罗向东 宋关斌 王红兵 吴云鹏 |
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| 作者单位： | 重庆大学生物工程研究院，第三军医大学烧伤研究所 |
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| 基金项目： | 国家教委资助优秀年轻教师基金 |
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| 摘 要： | 本文以大鼠作为烧伤的实验动物模型，以微管吸吮技术研究了烧伤情况下粒细胸（ＰＭＮ）与肺毛细血管内皮细胞（ＰＣＥＣ）的粘附力学特性．作者首先测定了ＰＭＮ与ＰＣＥＣ间的粘附力Ｆａ，进而在实验条件下定义了相对粘附应力Ｓ１．实验结果表明：在烧伤后２４小时内，粒细胞与肺毛细血管内皮细胞间的粘附力及相对粘附应力均显著升高，且在烧伤后１小时达到最大值。结合烧伤早期的病理变化，作者对实验结果进行了一定的分析和讨论．
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| 关 键 词： | 烧伤 多形核粒细胞 肺毛细血管内皮细胞 微管吸吮 大鼠 |
Investigation on the Mechanical Properties of Adhesion between Granulocytes and Endothelial Cells in Burnt Rats |
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| Wu Zezhi, Li Zhiqing, Long Mian, Luo XiangdongSong Guanbin, Wang Hongbin, Wu Yunpeng.Investigation on the Mechanical Properties of Adhesion between Granulocytes and Endothelial Cells in Burnt Rats[J].Journal of Biomedical Engineering,1996(3). |
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| Authors: | Wu Zezhi Li Zhiqing Long Mian Luo XiangdongSong Guanbin Wang Hongbin Wu Yunpeng |
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| Abstract: | 44 rats were used as experimental animal model to investigate the mechanieal properties of adhesion between polymorphonuclear granulocytes (PMN) and pulmonary capillary endothelial cells (PCEC) under burn conditions by means of micropipette aspiration technique. The authors first measured the adhesive forces (F.) between PMN and PCEC, then defined a relative adhesion stress (SI ) under the experimental conditions. The results showed that within a 24-hour POstburn duration, both the adhesive forces and the relative adhesion stresses between PMNs and PCECs increased obviously and reached their highest values at the moment I hr after burning. Abrief analysis and discussion on the results in relation to the early pathologiLJI changes of burning was presented. |
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| Keywords: | Burn Polymorphonuclear granulocyte Pulmonary capillary endothelial cell Micropipette aspiration Rat |
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