基于瞬态超声技术的软骨膨胀观测和模量提取

关节软骨结构和成分的细微变化都会导致软骨组织的退化,如骨关节炎,研究软骨的材料属性具有重要意义.本文基于瞬态超声技术实时观测关节软骨样品的渗透性膨胀过程,计算软骨在不同深度因膨胀产生的应变,并结合Narmoneva的三相模型提取其轴向弹性模量.结果显示,由于软骨组织膨胀引起的应变随深度变化而变化,深层组织的应变小,表层和中层组织的应变大.弹性模量也揭示了深层软骨的硬度(E1=12.20)明显比表层软骨硬度高(E2=0.15).研究结果显示,瞬态超声技术结合三相模型提供了一种定量研究软骨退化程度的方法.

Swelling Observation and Modulus Extraction of Cartilage Based on Transient Ultrasonic

Subtle changes in structure or composition can lead to degeneration of articular cartilage such as in osteoarthritis, so it is significant to study the materials attribute of the degenerating articular cartilage. A new transient ultrasonic technique was introduced into this study for measuring the swelling effects of the degenerated cartilage. The swelling-induced strain was calculated based on the measurement result, and then the uniaxial module of the articular cartilag was extracted using Narmoneva's triphasic model. The ultrasonic observation showed that the strains induced by the nonuniform swelling are depth-dependent, and the strains are small in the deep zone and big in the middle and surface zones. The uniaxial modulus also revealed that the cartilage in the deep zone (E1 = 12.20) is harder than that in surface zone (E2 = 0.15). These results suggest that the transient ultrasound technique accompanied by triphasic model provides a quantitative means to study the degeneration of articular cartilage.