自发性高血压大鼠胸主动脉的结构重建及力学特性

选取自发性高血压大鼠ＳＨＲ在高血压形成前后的不同时相点，采用组织形态学方法结合计算机图像分析，对ＳＨＲ大鼠胸主动脉几何形态及纤维结构进行了形态定量学研究，测定了ＳＨＲ胸主动脉零应力状态张开角的变化及压力－直径关系。结果表明，随着血压增高，ＳＨＲ主动脉几何形态及各种显微结构指标均显著增大；高血压形成和发展阶段，ＳＨＲ主动脉零应力状态张开角增大；高血压主动脉结构重建例如管壁增厚，胶原纤维不成比例地增加

Remodeling and Biomechanical Properties of Thoracic Aorta in Spontaneously Hypertensive Rats

Morphometry and microstructure of thoracic aorta of spontaneously hypertensive rats (SHR) at different periods before and after hypertension were studied quantitatively by histological method and computer image analysis. We also observed the changes of opening angle in the zero stress state and the relationship between pressure and diameter in SHR during established hypertension. The results showed that with blood pressure chronically increasing, there was a significant increase in morphometric parameters and microstructure parameters of the thoracic aorta in SHR. The zero stress state of opening angle in SHR during established hypertension increased significantly. These reults suggest that aortic structural remodeling in hypertension such as thickness of vascular wall and disproportional increase of collagen may lead to decrease in distensibility of the aorta in SHR. The structural remodeling and changes of mechanical properties in aorta may contribute to the important pathophysiology of hypertension induced complications.