| PCOS遗传基因研究进展 |
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| 引用本文： | 孙林,关咏梅.PCOS遗传基因研究进展[J].中国优生与遗传杂志,2006,14(8):113-116. |
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| 作者姓名： | 孙林 关咏梅 |
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| 作者单位： | 哈尔滨医科大学附属第二医院妇产科,150086 |
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| 基金项目： | 哈尔滨医科大学校科研和教改项目 |
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| 摘 要： | 多囊卵巢综合征(PCOS)是育龄妇女常见的生殖内分泌紊乱性疾病,为异质性病变,临床表现各异,其主要内分泌特征为高雄激素血症、高胰岛素血症和胰岛素抵抗、LH水平和LH/FSH比值升高。迄今为止,PCOS的发病机制还不清楚,PCOS患者的高度家族聚集性提示遗传因素在发病中起重要作用,遗传学研究表明影响这些激素代谢和调节的多种基因参与了PCOS的发生发展过程。
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| 关 键 词： | 多囊卵巢综合征 基因 遗传学研究 多态性 |
| 文章编号： | 1006-9534(2006)08-0113-04 |
| 修稿时间： | 2006年4月21日 |
The advance in the genetic study on PCOS |
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| SUN Lin,GUAN Yong-mei.The advance in the genetic study on PCOS[J].Chinese Journal of Birth Health & Heredity,2006,14(8):113-116. |
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| Authors: | SUN Lin GUAN Yong-mei |
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| Abstract: | Polycystic ovary syndrome(PCOS)is one of the reproductive endocrine disorders which usually affects those wome who are in the reproductive age.The clinical manifestation of PCOS varies,for which it belongs to one of the heterogenous diseases.The main endocrine characteristics of PCOS include hyperandrogenism,hyperinsulinemia,metabolic abnormalities,the increasing level of luteinizing hormone(LH),and the increasing ratio of LH and follicle-stimulating hormone(FSH)The aetiopathogenesis of this syndrome is not well known so far.The genetic studies show that many genes which influence the metabolism and modulation of these hormones may involve in pathogenesis of PCOS. |
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| Keywords: | PCOS Gene Genetic study Polymorphism |
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