基于薄层标本断面建立可视性三维颅底模型*

目的：为了帮助临床医生学习颅底解剖，创建一个颅底三维模型。方法：应用冷冻铣切技术，获得横断和 冠状薄层断面照片，对于系列照片进行分割、标志、提取颅底结构信号，然后通过Amira 3D 软件，重建了1 个颅 底三维模型。结果：共获得了780 张冠状断面和430 张横断面图片，在这些断面上，颅底的一些精细解剖结构可 以被追踪。成功重建的颅底3D模型可以在任何模式旋转和缩放。但是，因为该模型是在2 个头部标本的基础上 建立的，颅底解剖的变异不能被该模型显示。结论：重建的3D模型可以准确展示颅底解剖结构，它有利于外科 解剖培训，可用来完成术前的手术模拟。

A three-dimensional virtual model of the central skull base constructed from thin head-specimen sections*

Objective To create a three-dimensional （3D） model of the central skull base for doctors to master the regional anatomy. Methods Continuous thin sections in the transverse and coronal planes were performed with the freezing milling technique. After segmenting， labeling， and extracting organs in serial sections， we reconstructed the 3D model of the central skull base using Amira software. Results Seven hundred and eighty thin coronal sections， four hundred and thirteen transverse sections of the base region in central skulls were obtained. The salient structures could be tracked across sections. A 3D model of the central skull base that can be rotated and zoomed in an arbitrary fashion was successfully produced. There were some non-anatomical anomalies in the model because it was reconstructed with organs from two head spicimens. Conclusion The 3D model of the central skull base displays fine anatomical features. It is beneficial for surgical education in general and provides a means of preoperative rehearsal of skull-base surgical procedures.