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| 切应力对内皮细胞膜流动性的影响 | |
| 引用本文： | 顾兴华,王华,王克强,赵子琴,汪洋,贾剑国.切应力对内皮细胞膜流动性的影响[J].解剖学杂志,2000,23(4):352-354. |
| 作者姓名： | 顾兴华 王华 王克强 赵子琴 汪洋 贾剑国 |
| 作者单位： | 1. 上海医科大学解剖学教研室,上海,200032 2. 上海市胸科医院麻醉科,上海,200032 3. 上海医科大学法医学教研室,上海,200032 |
| 摘 要： | 目的：探讨切应力对内皮细胞膜流动性的影响。方法：选择１５ｄｙｎｅ／ｃｍ＾２、５０ｄｙｎｅ／ｃｍ＾２、３００ｄｙｎｅ／ｃｍ＾２三种切应力，分别模拟大中动脉处，大中动脉分叉处及病理状态下的切应力，以体外培养的人脐静脉内皮细胞作为实验对象，分别测定三组切应力作用０ｈ、１ｈ、２ｈ、４ｈ、６ｈ、１０ｈ的内皮细胞膜流动性。结果：切应力可降低内皮细胞膜液动性，且切应力越大，作用越强。切应力作用４ｈ，内皮细胞膜流 |
| 关 键 词： | 脐静脉 内皮细胞 膜流动性 切应力 动脉粥样硬化 |
EFFECT OF SHEAR STRESS ON ENDOTHELIUM MEMBRANE FLUIDITY |
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| Gu Xinghua,Wang Hua,Wang Keqiang,Zhao Ziqin,Wang Yang,Jia Jianguo.EFFECT OF SHEAR STRESS ON ENDOTHELIUM MEMBRANE FLUIDITY[J].Chinese Journal of Anatomy,2000,23(4):352-354. | |
| Authors: | Gu Xinghua Wang Hua Wang Keqiang Zhao Ziqin Wang Yang Jia Jianguo |
| Institution: | Gu Xinghua ; (Department of Anatomy, Shanghai Medical University, Shanghai, 200032,); Wang Hua ; (Department of Aneasthesiology, Shanghai Thoracic Hospital); Wang Keqiang ; (Department of Anatomy, Shanghai Medical University, Shanghai, 200032,); Zhao Ziqin ; (Department of Forensic Mediicine, Shanghai Medical University); Department of Anatomy, Shanghai Medical University, Shanghai, 200032, ; (Wang Yang); Department of Anatomy, Shanghai Medical University, Shanghai, 200032, ; (Jia Jianguo) |
| Abstract: | To study the effect of shear stress on endothelium membrane fluidity. Methods: The culture HUVECs were treated with 3 kinds of shear stress: 15, 50, 300 dyne/cm 2 (imitating the shear stresses of the middle big artery, the bifurcation of the middle big artery, the pathological place of the artery). The membrane fluidity of the 3 groups was detected at 0,1,2,4,6,10 h. Results: The shear stress decreased the membrane fluidity. The higher shear stress, the lower the membrane fluidity. It arrived at the lowest point in 4 h, then kept at this level. Conclusion: The shear stress affects the membrane fluidity apparently, it changes the function of EC, take part in the production and development of atherosclerosis. |
| Keywords: | artery umbilical vein endothelial cell membrane fluidity shear stress |
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