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| 龟龄集对大鼠海马结构内突触小泡蛋白年龄变化的影响 | |
| 引用本文： | 任占川,侯迎潮,王树党,徐玲琳,魏建宏,郭连魁.龟龄集对大鼠海马结构内突触小泡蛋白年龄变化的影响[J].解剖学杂志,2000,23(6):563-567. |
| 作者姓名： | 任占川 侯迎潮 王树党 徐玲琳 魏建宏 郭连魁 |
| 作者单位： | 1. 山西医科大学汾阳学院,汾阳,032200 2. 山西医科大学实验中心图像分析室 3. 山西省汾阳医院 4. 山西医科大学神经生物研究室 |
| 摘 要： | 目的：研究大鼠海马结构内突触小泡蛋白年龄变化的影响。方法：实验用Ｗｉｓｔａｒ大鼠、免疫组织化学结合图像分析法。结果：２４月龄大鼠齿状回多形层、海马ＣＡ３辐射层内突触小泡蛋白免疫反应产物的灰度值明显大于１８月龄鼠（Ｐ＜０．００１，Ｐ＜０．００５）；１２月龄鼠经６和１２个月服用龟龄集后，齿状回多形层、海马ＣＡ３辐射层内突触小泡蛋白免疫反应产物的灰度值均比同龄对照组显著降低（Ｐ＜０．０５）。结论：大鼠海马结构内突触小泡蛋白随着年龄的增加而减少；服用龟龄集可延缓神经元的衰老，防止海马结构内突触小泡蛋白的丢失，改善学习记忆功能。 |
| 关 键 词： | 龟龄集 突触小泡蛋白 海马 衰老 中成药 |
EFFECTS OF GUI LINGJI ON AGE-RELATED CHANGES OF SYNAPTOPHYSIN IN RATS' HIPPOCAMPAL FORMATION |
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| Ren Zhanchuan,Hou Yinchao,Wang Shudang,Xu Linglin,Wei Jianhong,Guo Liankui.EFFECTS OF GUI LINGJI ON AGE-RELATED CHANGES OF SYNAPTOPHYSIN IN RATS' HIPPOCAMPAL FORMATION[J].Chinese Journal of Anatomy,2000,23(6):563-567. | |
| Authors: | Ren Zhanchuan Hou Yinchao Wang Shudang Xu Linglin Wei Jianhong Guo Liankui |
| Abstract: | Objective: To study age related changes of synaptophysin in rat' hippocampal formation and Guilingji's influence on it. Methods: Immunohistochemistry combined with image analysis was used. Results: The gray density of immunoreactive products of synaptophysin in rats' polymporph layer dentate gyrus and hippocampus stratum radiatum of CA 3 area of 24 month rat's was obviously higher than that of 18 month one(P<0.001, P<0.005). 12 month rats, after taking Guilingji for 6 and 12 months respectively, their synaptophysin immunoreactive products gray density decline remarkably than the control groups of the same age(P<0.005). COnclusion: The synaptophysin in rats' hippocampal formation decrease with growing; taking Guilingji can delay neuron aging and prevent synaptophsin in hippocampal formation from decreasing. |
| Keywords: | Guilingji synaptophysin hippocampus aging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |