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| 亚硒酸钠对大鼠胃癌变前期胃窦粘膜G、D和EC细胞的影响 | |
| 引用本文： | 吴春云,唐军民,李枫,唐岩,毕振伍,朴建华.亚硒酸钠对大鼠胃癌变前期胃窦粘膜G、D和EC细胞的影响[J].解剖学杂志,2000,23(4):355-359. |
| 作者姓名： | 吴春云 唐军民 李枫 唐岩 毕振伍 朴建华 |
| 作者单位： | 1. 昆明医学院组织学与胚胎学教研室,昆明,650031 2. 北京医科大学组织学与胚胎学系 3. 中国预防医学科学院营养与食品卫生研究所 |
| 摘 要： | 目的：探讨亚硒酸钠对大鼠胃癌变前期胃窦粘膜Ｇ细胞、Ｄ细胞和ＥＣ细胞的影响。方法：用免疫组织化学及图像分析法，观察亚硒酸钠对Ｎ－甲基－Ｎ’－硝基－Ｎ－亚硝基胍诱发的大鼠胃癌变前期胃窦粘膜Ｇ细胞、Ｄ细胞和ＥＣ细胞的变化。结果：Ｎ－甲基－Ｎ’硝基－Ｎ－亚硝基胍短期灌胃后（阳性对照组），胃窦粘膜Ｇ、Ｄ、ＥＣ细胞的数量和平均光密度值（ＯＤ值）与正常对照组比较均显著减少（Ｐ〈０．０１）。Ｎ－甲基－Ｎ’－硝基－ |
| 关 键 词： | 胃癌 胃窦粘膜 G细胞 D细胞 EC细胞 亚硒酸钠 |
EFFECTS OF SODIUM SELENITE ON G,D AND EC CELL IN ANTRAL MUCOSA OF EXPERIMENTALLY INDUCED PRECANCEROUS LESIONS IN RATS |
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| Wu Chunyun,Tang Junmin,Li Feng,Tang Yan,Bi Zhenwu,Piao Jianhua.EFFECTS OF SODIUM SELENITE ON G,D AND EC CELL IN ANTRAL MUCOSA OF EXPERIMENTALLY INDUCED PRECANCEROUS LESIONS IN RATS[J].Chinese Journal of Anatomy,2000,23(4):355-359. | |
| Authors: | Wu Chunyun Tang Junmin Li Feng Tang Yan Bi Zhenwu Piao Jianhua |
| Institution: | Wu Chunyun ; (Department of Histology and Embryology,Kunming Medical College,Kunming 650031); Tang Junmin ,Li Feng ,Tang Yan ,Bi Zhenwu ; (Department of Histology and Embryology,Beijing Medical University); Piao Jianhua ; (Institute of Nutriton and Food Hygiene,Chinese Acaemic of Preventive Medicine) |
| Abstract: | To study the influence of sodium selenite on G, D and EC cell in antral mucosa of experimentally precancerous lesions. Methods: Using immunohistochemistry ABC methods and image analysis, the effects of sodium selenite on G, D and EC cell in antral mucosa of precancerous lesions by N methyl N' nitro N nitrosoguanidine(MNNG) were oserved. Results: the numbers and optic density(OD) of G, D and EC cells in antral mucosa were significantly decreased after given MNNG for a short term (P<0.01). The forage contained sodium selenite was applied after given MNNG in rats. The number of G cell in low dose group were not changed compared with control group (P>0.05), but the optic density was significantl increased (P<0.01). The numers and optic density of G cell in high dose group were significantly increased compared with control (P<0.05, 0.01 respectively). The numbers and optic density of EC cell in low and high dose groups were significantly increased compared with control group(P<0.05, 0.01 respectively). No significant change was found in D cell. Conclusion: G cell, EC cell in antral mucosa are possibly involved in anti precancereous lesions of sodium selenite in rats. |
| Keywords: | stomach stomach mucosa endocrine cell stomach cancer |
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