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Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies |
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| Authors: | Faour Wissam H. Choaib Ali Issa Elio Choueiry Francesca El Shbaklo Khodor Alhajj Maryline Sawaya Ramy Touma Harhous Zeina Alefishat Eman Nader Moni |
| Affiliation: | 1.Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon ;2.Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates ;3.Department of Physiology and Immunology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates ;4.Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates ;5.Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, Jordan ; |
| Abstract: | The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness. |
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