Historical evolution,overview, and therapeutic manipulation of co-stimulatory molecules |
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| Authors: | Henry Velazquez-Soto Fernanda Real Maria C Jim&# nez-Mart&# nez |
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| Institution: | Henry Velazquez-Soto, Fernanda Real, Maria C Jiménez-Martínez, Department of Immunology and Research Unit, Institute of Ophthalmology “Conde de Valenciana”, Mexico City 06800, MexicoMaria C Jiménez-Martínez, Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico |
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| Abstract: | Co-stimulatory molecules are key mediators in the regulation of immune responses and knowledge of its different families, structure, and functions has improved in recent decades. Understanding the role of co-stimulatory molecules in pathological processes has allowed the development of strategies to modulate cellular functions. Currently, modulation of co-stimulatory and co-inhibitory molecules has been applied in clinical applications as therapeutic targets in diseases and promising results have been achieved. |
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| Keywords: | Co-stimulatory molecules Immune modulation Monoclonal antibodies Biological therapy Autoimmune diseases Oncological diseases |
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