皮瓣缺血再灌注损伤治疗研究进展

在皮瓣移植术后常常会发生缺血再灌注损伤,缺血再灌注损伤是引起皮瓣部分或全部坏死的重要原因.目前对皮瓣缺血再灌注损伤的发病机制尚不清楚,大多数学者认为可能与细胞凋亡、炎性反应、组织微循环障碍、细胞氧化损伤等有关.学者们提出用缺血预处理,药物干预,减少炎性反应,移植干细胞或干细胞联合基因疗法,体外冲击波,抗氧化反应和抑制细...

Advances in Skin Flap Ischemia-Reperfusion Injury

Ischemia-reperfusion injury often occurs after skin flap transplantation,and may lead to partial or complete necrosis of the skin flap.However,the pathogenesis of flap ischemia-reperfusion injury remains unclear.Previous studies imply that its pathogenesis may be related to cell apoptosis,inflammatory response,tissue microcirculation disorder,and cell oxidative damage.The treatments for reducing the flap ischemia-reperfusion injury in previous studies include the use of is-chemic preconditioning,drug intervention,reduction of inflammatory response,transplantation of stem cells or stem cell-based gene therapy,extracorporeal shock wave,antioxidant response,and inhibition of cell apoptosis.This article reviews the recent experimental researches on skin flap ische-mia-reperfusion injury treatment and their clinical applications,which aims to provide theoretical basis and new ideas for the treatment of skin flap ischemia-reperfusion injury.