| CIK细胞的体外培养与细胞毒作用 |
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| 引用本文： | 秦莉,王志华.CIK细胞的体外培养与细胞毒作用[J].医学分子生物学杂志,2007,4(1):82-85. |
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| 作者姓名： | 秦莉 王志华 |
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| 作者单位： | 哈尔滨医科大学肿瘤防治研究所,哈尔滨市,150081 |
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| 基金项目： | 黑龙江省重点攻关课题(No.G00C190401)~~ |
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| 摘 要： | CIK(cytokine-induced killer)细胞在体外可以快速扩增,具有高效的非MHC限制性杀瘤活性,被认为是抗肿瘤过继细胞免疫治疗的新希望。随着细胞操作及基因修饰技术的日益精进,人们正逐渐改进CIK细胞的体外培养和处理方法,以便进一步提高CIK细胞的增殖率及特异杀伤力,使其更好地应用于临床。
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| 关 键 词： | CIK细胞 体外培养 细胞毒作用 |
| 修稿时间： | 2006年7月3日 |
In Vitro Culture and Cytotoxicity of Cytokine-Induced Killer Cells |
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| QIN Li,WANG Zhihua.In Vitro Culture and Cytotoxicity of Cytokine-Induced Killer Cells[J].Journal of Medical Molecular Biology,2007,4(1):82-85. |
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| Authors: | QIN Li WANG Zhihua |
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| Abstract: | Cytokine-induced killer(CIK)cells are newly discovered immuno-competent cells that have application in adoptive cellular immunotherapy.These cells mediate highly efficient non-major histocompatibility complex(MHC)-restricted killing of tumor cell targets and proliferate rapidly in vitro.With the advances in the research on cellular manipulation and genetic modification,efforts are now directed to finding approaches to increase the growth rate and specific cytotoxicity of CIK cells for clinical application by improving the in vitro culture and treatment methods. |
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| Keywords: | CIK cell culture in vitro specific cytotoxicity clinical application |
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