IL-32与肿瘤生物学行为

肿瘤是威胁人类健康的重大疾病，其进程与肿瘤微环境密切相关。炎性介质是肿瘤微环境的重要组分， IL?32是一种炎性因子，主要由免疫细胞及上皮细胞表达，目前共发现IL?32α、β、γ、δ、ε、η、s、θ、ζ9种亚型。 IL?32可诱导IL?6、 IL?8、 IL1β等介质的表达，参与炎性疾病的进程，还可以通过NF?κB （核因子κB）、 MMP?2（基质蛋白酶2）等信号通路影响乳腺癌、宫颈癌、胃癌、肝癌等肿瘤的侵袭转移、增殖和凋亡。文章介绍了IL?32的发现、生物结构、分泌及其受体， IL?32在肿瘤微环境中的表达特点及其对肿瘤的生物学效应，旨在为IL?32的研究及肿瘤分子靶向治疗提供思路。

Advances of Interleukin-32 in Cancer

Cancers pose a substantial threat to human health and their development is closely related to tumor microenvironment. Inflammatory mediators are an important component of tumor mi?croenvironment. Interleukin?32 ( IL?32 ) , a kind of inflammatory cytokine, is predominantly ex?pressed in immune and epithelial cells. So far nine isoforms including IL?32α, β, γ, δ, ε, η, s, θ, and ζ have been found. IL?32 takes part in the progress of inflammatory disease by inducing the expression of such inflammatory cytokines as IL?6 , IL?8 and IL1β. And it is involved in the in?vasion, metastasis, proliferation and apoptosis of breast cancer, cervical cancer, gastric cancer and liver cancer and so on via the signaling pathways such as NF?κB and MMP?2. In this review, we elucidate the discovery of IL?32, its biological structure, its secretion and receptors. We discuss the expression features of IL?32 in tumor microenvironment and biological effects of IL?32 on tumors in an attempt to provide clues for the application of IL?32 to the molecular targeted therapy of tumors.