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The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy |
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| Authors: | Claire S Reader Sabari Vallath Colin W Steele Syed Haider Adam Brentnall Ami Desai Kate M Moore Nigel B Jamieson David Chang Peter Bailey Aldo Scarpa Rita Lawlor Claude Chelala Stephen M Keyse Andrew Biankin Jennifer P Morton TR Jeffry Evans Simon T Barry Owen J Sansom Hemant M Kocher John F Marshall |
| Institution: | 1. Cancer Research UK Beatson Institute, Glasgow, UK;2. Institute of Cancer Research, London, UK;3. Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK;4. Centre for Tumour Biology, Barts Cancer Institute, CRUK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, London, UK;5. Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK;6. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK;7. ARC-NET Research Centre for Applied Research on Cancer, University of Verona, Verona, Italy;8. Centre for Molecular Oncology, Barts Cancer Institute, CRUK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, London, UK;9. Division of Cancer Research, University of Dundee, James Arrott Drive, Ninewells Hospital and Medical School, Dundee, UK;10. Cancer Research UK Beatson Institute, Glasgow, UK Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK;11. Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK |
| Abstract: | |
| Keywords: | PDAC integrin 264RAD αvβ6 pancreas cancer transgenic mouse model |