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Interleukin-7 Receptor Signaling Network: An Integrated Systems Perspective
作者姓名:Palmer MJ  Mahajan VS  Trajman LC  Irvine DJ  Lauffenburger DA  Chen J
基金项目:The authors would like to thank Alfred Singer, Jung-Hyun Park and Chris Govern for helpful discussions. This work was partially supported by NIH grants AI40146, AI69208 and CA100875 (to J. C.) and P50-068762 and AI06582 (to D. A. L.), and by a grant from Arnold and Mabel Beckman Foundation (to D.J.I.)
摘    要:Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology. Cellular & Molecular Immunology.

关 键 词:白细胞介素-7  受体  细胞因子  生物学

Interleukin-7 receptor signaling network: an integrated systems perspective
Palmer MJ,Mahajan VS,Trajman LC,Irvine DJ,Lauffenburger DA,Chen J.Interleukin-7 receptor signaling network: an integrated systems perspective[J].Cellular & Molecular Immunology,2008,5(2):79-89.
Authors:Palmer Megan J  Mahajan Vinay S  Trajman Lily C  Irvine Darrell J  Lauffenburger Douglas A  Chen Jianzhu
Institution:[1]Department of Biological Engineering [2]Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Abstract:Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstaik, shared interaction domains, feedback loops, integrated gene regulation, muitimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.
Keywords:IL-7 receptor  cytokine  signaling network  systems biology  modeling
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