| Role of Leptin in Immunity |
| |
| 作者姓名： | Lam QL Lu L |
| |
| 作者单位： | Department of Pathology and Center of Infection and Immunology, TheUniversity of Hong Kong, Hong Kong, China |
| |
| 基金项目： | 香港大学校科研和教改项目 |
| |
| 摘 要： | Leptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis. Cellular ＆ Molecular Immunology. 2007;4（1）：1-13.
|
| 关 键 词： | 瘦素 免疫反应 信号传导 促炎症细胞因子 自体免疫性疾病 |
| 收稿时间： | 2007-02-04 |
| 修稿时间： | 2007-02-12 |
Role of leptin in immunity |
| |
| Lam QL,Lu L.Role of Leptin in Immunity[J].Cellular ＆ Molecular Immunology,2007,4(1):1-13. |
| |
| Authors: | Lam Queenie Lai Kwan Lu Liwei |
| |
| Institution: | Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China. |
| |
| Abstract: | Leptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis. |
| |
| Keywords: | leptin leptin signaling pro-inflammatory cytokine immune response autoimmune disease |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
