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基于定量动态负荷下膝关节骨性关节炎软骨MRIT2时间表现研究
引用本文:李智慧,周海宇,奚小冰,李元超,陆勇,杜联军,丁晓毅,严福华.基于定量动态负荷下膝关节骨性关节炎软骨MRIT2时间表现研究[J].生物医学工程与临床,2013(6):557-561.
作者姓名:李智慧  周海宇  奚小冰  李元超  陆勇  杜联军  丁晓毅  严福华
作者单位:[1]上海交通大学医学院附属瑞金医院放射科,上海200020 [2]上海交通大学医学院附属瑞金医院骨伤科,上海200020 [3]上海交通大学机械与动力工程学院,上海200032
基金项目:上海市科委基础研究创新行动计划(09JCl409800);上海市科委中医专项课题(09dzl972000)
摘    要:目的通过比较膝关节骨性关节炎(OA)病人定量动态负荷前后膝关节软骨T2时间变化情况,分析MRIT2mapping序列反映软骨基质生物力学变化的灵敏度.并验证高磁场条件下人体关节负荷装置的有效性。方法10例膝关节OA病人,其中男性3例.女性7例:年龄4l~66岁.平均年龄57-3岁。依托人体下肢关节力学负荷装置,对其施加膝关节动态负荷。负荷前后行膝关节MRIT2maDping成像,将膝关节轴向负荷区软骨分为4个部位:胫骨平台内、外侧软骨区及股骨内、外侧髁软骨区.分别测量各部位软骨负荷前后的T,时间。对负荷前膝关节内、外侧软骨分级评估进行卡方检验,对同一软骨区动态负荷前后的T2时间进行配对t检验。结果负荷前膝关节内外侧软骨分级差异无统计学意义(P〉0.05)。OA病人负荷前后T2值,胫骨平台内侧软骨区分别为(39.59±4.17)ms、(40.14±4.49)ms(f=0.426,P=0.680);胫骨平台外侧软骨区(38.85±6.72)ms、(41.25±6.54)ms(t=1.704,P=0.123):股骨内侧髁软骨区(36.44±5.72)ms、(40.63±4.90)ms(t=1.783,P=0.108);股骨外侧髁软骨区(39.30±5.78)ms、(46.14±5.03)ms(t=2.826,P=0.020)。结论OA病人负荷后膝关节局部区域软骨区T2时间延长.自行设计的动态加压装置适合在高磁场条件下完成加压及MRI检查,有一定推广意义。

关 键 词:膝关节骨性关节炎  关节软骨  动态负荷  磁共振成像  T2时间

Study on MRI T2 times of articular cartilage in knee osteoarthritis based on quantitative dynamic load
LI Zhi-hui,ZHOU Hai-yu,XI Xiao-bing,LI Yuan-chao,LU Yong,DU Lian-jun,DING Xiao-yi,YAN Fu-hua.Study on MRI T2 times of articular cartilage in knee osteoarthritis based on quantitative dynamic load[J].Biomedical Engineering and Clinical Medicine,2013(6):557-561.
Authors:LI Zhi-hui  ZHOU Hai-yu  XI Xiao-bing  LI Yuan-chao  LU Yong  DU Lian-jun  DING Xiao-yi  YAN Fu-hua
Institution:1.ca Department of R(utiology; b. Department of Traumatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, Chino; 2. Department of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200032, China)
Abstract:Objective To compare the T2 times of quantitative dynamic load area of articular cartilage in the patients with osteoarthritis (OA), and analyze the sensitivity of magnetic resonance imaging(MRI) T2 mapping sequence to the biomechanical changes in cartilage matrix, and verify the clinical effectiveness of human joint loading device. Methods A total of 10 OA patient were enrolled, included 3 males and 7 females, aged 41 - 66 years old with a mean age of 57.3. Dynamic loads were imposed on self-designed human lower limb mechanical loading device. The MRI T2 mapping of knee before and after loading was performed. The axial loading area of knee cartilage was divided into 4 compartments: medial tibial cartilage area, lateral cartilage area, medial femoral condyle cartilage area and lateral femoral condyle cartilage area. The T2 values of 4 portions were measured. Evaluation of staging of knee cartilage before loading was compared by chi-square test. The statistical analysis of paired t test of T: values of the same place were performed with SPSS 16.0. Results There was no significant difference in knee medial and lateral cartilage grading before loading(P 〉 0.05). The mean T2 times of OA knee cartilage, the before and after dynamic loading were (39.59 ± 4.17) ms and (40.14± 4.49) ms(t = 0.426, P= 0.680) in medial tibia cartilage area; (38.85 ± 6.72) ms and (41.25 ± 6.54) ms(t = 1.704, P= 0.123) in lateral tibia cartilage area; (36.44 ± 5.72) ms and (40.63 ± 4.90) ms(t = 1.783, P = 0.108) in medial femoral condyle cartilage area; (39.30 ± 5.78) ms and (46.14 ± 5.03) ms(t = 2.826, P = 0.020) in lateral femoral condyle cartilage area, respectively. Conclusion It is demonstrated that quantitative dynamic loading resulted in significant increase in T2 times of lateral femoral cartilage. The self-designed dynamic loading device could complete loading and MRI at high pressure conditions.
Keywords:knee osteoarthritis  cartilage  dynamic loading  magnetic resonance  T2 times
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