乳酸／羟基乙酸共聚物-壳聚糖膜支架的制备及体外性质研究

目的制备乳酸，羟基乙酸共聚物（PLGA）-壳聚糖（CS）接枝化合物．改善PLGA薄膜的亲水性。方法利用PLGA端基的羧基与CS进行反应，从而在PLGA长链上共价键合CS。通过傅立叶变换红外光谱（FTIR）、差示扫描热分析法（DSC）、热重分析法（TGA）、X射线光电子能谱法（XPS）对其结构和热力学性质进行表征，利用接触角评价PLGA—CS薄膜表面亲水性能。结果通过共价结合的方式制备了CS改性PLGA化合物．该接枝化合物热稳定性和亲水性能都较PLGA有了明显提高。结论成功制备了不同接枝比例的CS改性PLGA化合物．该薄膜的亲水性能得到了较大的改善．拓展了该类型材料在生物医学工程领域的廊用范围．

Study on preparation of PLGA-CS composite membrane scaffold and its characteristics in vitro

Objective To construct poly（lactic-co-glycolic acid）-chitosan（PLGA-CS） membranes for improving the hydrophilicity of PLGA. Methods The physieochemical and thermal properties were characterized by Fourier transform infrared spectroseopy（FTIR）, differential scanning calorinietery（DSC）, thermogravimetrie analysis（TGA） and X-ray photoemission spectroscopy （XPS）. The hydrophilicity of membranes was characterized by contact angle method. Results The PLGA -CS membranes were prepared by covalent binding method. The results demonstrated the thermal stability and hydrophilicity of PLGA-CS membranes increased. Conclusion The PLGA-CS membrane has been successfully prepared and it processes good hydrophilicity and will meet the requirement for tissue engineering. It provides the possibility of producing new bespoke materials for potential biomedical applications.