| Bmi-1在子宫颈癌中的表达及临床意义 |
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| 引用本文： | 龚宝兰,王任晓,陈永利,胡平. Bmi-1在子宫颈癌中的表达及临床意义[J]. 局解手术学杂志, 2011, 20(4): 364-366 |
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| 作者姓名： | 龚宝兰 王任晓 陈永利 胡平 |
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| 作者单位： | 郧阳医学院附属人民医院妇产科,湖北,十堰,442000 |
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| 摘 要： | 目的探讨Bmi-1在子宫颈癌中的表达及临床意义。方法应用RT-PCR方法检测子宫颈癌中Bmi-1 mRNA表达,采用免疫组织化学法检测子宫颈癌中Bmi-1蛋白的表达情况。结果本组所有的子宫颈癌（100.0%）和绝大多数正常子宫颈组织（91.7%）都表达Bmi-1 mRNA,定量分析其在子宫颈癌中的表达量明显高于正常子宫颈组织（P〈0.05）,Bmi-1蛋白仅在子宫颈癌中散在表达。结论 Bmi-1是干细胞基因,其在子宫颈癌中的表达提示子宫颈癌干细胞的存在,其可能为子宫颈癌治疗的一个潜在靶点。
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| 关 键 词： | 子宫颈癌 Bmi-1 肿瘤病理学 |
Expressions and clinical significances of Bmi-1 in human cervical carcinoma |
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| GONG Bao-lan,WANG Ren-xiao,CHEN Yong-li,HU Ping. Expressions and clinical significances of Bmi-1 in human cervical carcinoma[J]. Journal of Regional Anatomy and Operative Surgery, 2011, 20(4): 364-366 |
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| Authors: | GONG Bao-lan WANG Ren-xiao CHEN Yong-li HU Ping |
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| Affiliation: | GONG Bao-lan,WANG Ren-xiao,CHEN Yong-li,HU Ping(Department of Obstetrics and Gynecology,Affiliated People's Hospital of Yunyang Medical College,Shiyan Hubei 442000,China) |
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| Abstract: | Objective To investigate the expressions and clinical significances of Bmi-1 in human cervical carcinoma.Methods The expressions of Bmi-1 mRNA in cervical carcinoma tissues were evaluated by RT-PCR and the expressions of Bmi-1 protein in cervical carcinoma tissues were detected by immunohistochemical staining.Results Bmi-1 mRNA was expressed in all cervical carcinomas(100%) and most of normal cervixs(91.7%).The expressions of Bmi-1 mRNA were higher in cervical carcinomas than those in normal cervixes(P<0.05... |
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| Keywords: | Bmi-1 |
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