慢性肾炎患者血浆leptin和血清IL-6、EL-18及SOD检测的临床意义

目的：探讨慢性肾炎患者治疗前后血浆leptin和血清IL-6、IL．18及SOD水平的变化及临床意义。方法：应用放射免疫分析和酶联免疫法对33例慢性肾炎患者进行了血浆leptin和血清IL-6、IL．18及SOD检测，并与35名正常健康人作比较。结果：慢性肾炎患者在治疗前血浆leptin和血清IL-6、IL．18均显着地高于正常人组（P〈0．01），而血清SOD水平则显着地低于正常人组（P〈0．01）。经中西医结合治疗3个月后与正常人组比较仍有显著性差异（P〈0．05），血浆leptin水平与血清IL-6、IL．18水平呈正相关（r=0．5718、0．4916，P〈0．01），而与SOD水平呈负相关（r=-0．6018，P〈0．01）。结论：检测慢性肾炎患者治疗前后血浆leptin和血清IL-6、IL-18及SOD水平的变化对临床观察和预后有重要的临床价值。

Clinical Significance of Measurement on Plasma Leptin and Serum IL-6, IL-18 and SOD Levels in Patients with Chronic Nephritis

Objective To explore the clinical significance of changes on plasma leptin and serum IL-6,IL-18,SOD levels after treatment in patients with chronic nephritis.Methods Plasma leptin and serum SOD(with RIA),serum IL-6,IL-18(with ELISA) levels were measured in 33 patients with chronic nephritis as well as 35 normal healthy controls.Results Before treatment,the plasma leptin and serum IL-6,IL-18 were obviously higher than those in controls(P < 0.01),while the serum SOD level was significantly lower(P < 0.01).After treatment for 3 months,the levels in patients though dropped markedly remained higher than those in controls (P <0.05 ).Plasma leptin level was positively correlated with IL-6,IL-8 levels(r = 0.5718,0.4916,P < 0.01),while the negative correlated with SOD level(r = - 0.6018,P < 0.01).Conclusion Changes of plasma leptin and serum IL-6,IL-18,SOD levels after treatment might be of prognostic importance in patients with chronic nephritis and provided important clinical value.