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血浆IL-6、TNF-α和皮质醇(8:00和24:00)水平诊断脑损伤严重程度的临床应用
引用本文:赵若愚,鲍选民,杨永青.血浆IL-6、TNF-α和皮质醇(8:00和24:00)水平诊断脑损伤严重程度的临床应用[J].放射免疫学杂志,2009,22(1):17-18.
作者姓名:赵若愚  鲍选民  杨永青
作者单位:苏州市立医院,215002
摘    要:目的:血浆IL-6、TNF-α和皮质醇(8:00和24:00)水平诊断脑损伤严重程度的临床应用。方法:检测112例脑损伤患者和59例正常对照组血浆IL-6、TNF-α和皮质醇(8:00和24:00)水平并做了比较分析。结果:112例脑损伤被分成重度、中度和轻度三组。112例脑损伤中IL-6、TNF-α和皮质醇(8:00和24:00)水平明显高于58例正常对照组,并随着脑损伤的严重程度,血浆IL-6、TNF-α和皮质醇(8:00和24:00)水平不断增加,与正常对照组比较(P均〈0.01)。重度脑损伤血浆IL-6、TNF-α和皮质醇(8:00和24:00)水平明显高于中度和轻度脑损伤(P〈0.05)。中度者稍高于轻度者但无明显差异(P〉0.05)。结论:血浆IL-6、TNF-α和皮质醇(8:00和24:00)测定是临床上诊断脑损伤严重程度的良好指标,并可据此采取必要的治疗手段。

关 键 词:脑损伤  白细胞介素-6(IL-6)  肿瘤坏死因子-α(TNF-α)  皮质醇

The Clinical Application of Determination of Plasma IL-6, TNF-α and Costisol (at 8:00 and 20:00) Levels for Assessment of Severity of the Disease in Patients with Acute Brain Injury
Zhao Ruoyu,Ban Yimin,Yang Yongqing.The Clinical Application of Determination of Plasma IL-6, TNF-α and Costisol (at 8:00 and 20:00) Levels for Assessment of Severity of the Disease in Patients with Acute Brain Injury[J].Journal of Radioimmanology,2009,22(1):17-18.
Authors:Zhao Ruoyu  Ban Yimin  Yang Yongqing
Institution:Zhao Ruoyu,Bao Yimin,Yang Yongqing Department of Emergency,Suzhou Manicipal Hospital,Suzhou,Jiangsu(215002)
Abstract:Objective To investigate the clinical usefulness of determination of plasma IL - 6, TNF - α and costisol ( at 8 : 00 and24:00) levelsin patents with acute brain injury. Methods PlasmaIL-6, TNF-atandcortisol (at8:00 and24:00) levels were determined with RIA in 112 patients with acute brain injury and 58 controls. The 112 patients were of 3 groups: (1) mild, Glascow score 13-15, n =46 (2) moderate, score9-12, n=31 (3) severe, score3 -8, n=35. Results The plasma IL-6, TNF - α and costisol ( at 8 : 00 and 24 : 00) levels were significantly higher in the patients with brain injury than those in the controls (P all 〈 0.01 ). The more severe the illnessuas, the higher IL - 6, TNF - α and costisol ( at 8 : 00 and 24 : 00) levels would be. Plasma IL - 6, TNF - α and costisol ( at 8 : 00 and 24 : 00) levels were significantly higher in the severe group than those in the mild and moderate groups ( P 〈 0.05). The plasma IL - 6, TNF - α and costisol at ( 8 : 00 and 24 : 00) levels were slightly but not significantly higher in the moderate group than those in the mild group ( P 〉 0.05). Conclusion Plasma IL - 6, TNF - α and corfisol levels could reflect the severity of the disease in patients with acute brain injury and determination of which would be clinically useful.
Keywords:brain injury  IL - 6  TNF - α  costisol
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