| 链球菌组蛋白样蛋白对人脐静脉血管内皮细胞产生TNF-α的影响 |
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| 引用本文： | 张力平,平国玲,李卫红,沈海中,张海燕,张红春,靖学芳,李玉兰.链球菌组蛋白样蛋白对人脐静脉血管内皮细胞产生TNF-α的影响[J].现代免疫学,2003,23(5):311-313. |
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| 作者姓名： | 张力平 平国玲 李卫红 沈海中 张海燕 张红春 靖学芳 李玉兰 |
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| 作者单位： | 1. 首都医科大学微生物学教研室,北京,100054
2. 细胞生物学教研室 |
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| 基金项目： | 北京市自然科学基金资助项目(No.7992003) |
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| 摘 要： | 研究链球菌HlpA对HUVEC产生TNF-α的作用。用1929成纤维细胞的细胞毒实验检测TNF-α活性。链球菌HlpA(0-80μg/ml)在体外以剂量和时间依赖方式促进HUVEC过量产生TNF-α(P<0.05)。LTA和HlpA的混合物对TNF-α的产生呈协同增强作用(P<0.05);抗HlpA和肝素则起抑制作用。
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| 关 键 词： | 链球菌 人脐带静脉血管内皮细胞 肿瘤坏死因子-α |
| 文章编号： | 1001-2478(2003)05-0311-03 |
| 修稿时间： | 2003年3月17日 |
Effects of Streptococcus Histone-Like Protein on the Production of TNF-α by Human Umbilical Cord Vein Vascular Endothelial Cells |
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| ZHANG Li-ping,PING Guo-ling,LI Wei-hong,SHEN Hai-zhong,ZHANG Hai-yan,ZHANG Hong-chun,JING Xue-fang,LI Yu-lan.Effects of Streptococcus Histone-Like Protein on the Production of TNF-α by Human Umbilical Cord Vein Vascular Endothelial Cells[J].Current Immunology,2003,23(5):311-313. |
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| Authors: | ZHANG Li-ping PING Guo-ling LI Wei-hong SHEN Hai-zhong ZHANG Hai-yan ZHANG Hong-chun JING Xue-fang LI Yu-lan |
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| Abstract: | To evaluate the effect of Streptococcus HlpA on the production of TNF-α by human umbilical cord vein vascular endothelial cells (HUVEC ) , the activity of TNF-α was determined by means of cytotoxicity assay with L929 cells. Streptococcus HlpA (0-80 μg/ml ) could induce an over-production of TNF-α by HUVEC cells in a dose and time dependent manner in vitro. There was a synergistic enhancing effect of the production of TNF-αinduced by a mixture of LTA and HlpA, and the anti-HlpA and heparin showed an inhibitory effect. |
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| Keywords: | Streptococcus HUVEC TNF-α |
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