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盖膜与内毛细胞静纤毛相互作用的生物力学分析
引用本文:杨琳,戴培东,华诚,张天宇,丁光宏,王克强,王正敏.盖膜与内毛细胞静纤毛相互作用的生物力学分析[J].解剖学报,2009,40(2):283-287.
作者姓名:杨琳  戴培东  华诚  张天宇  丁光宏  王克强  王正敏
作者单位:1.复旦大学力学与工程科学系,上海 200433;2.复旦大学附属眼耳鼻喉科医院中心实验室,上海 200031;3.复旦大学附属中山医院心血管病研究所,上海 200032
基金项目:国家自然科学基金面上项目,上海市重点学科建设项目 
摘    要:目的 探讨在Corti器振动过程中盖膜与内毛细胞静纤毛的相互作用关系;进一步阐明感音传导过程中,内耳Corti器微观结构可能的存在状态.方法 以豚鼠耳蜗底回Corti器的电镜图像为原型,建立盖膜与内毛细胞最长静纤毛接触和不接触的两种二维计算模型各一个,并作力学分析比较.结果模拟Corti器振动过程.在相同剪切流的压力作用下,静纤毛在不接触盖膜时表现偏移度较大;两种模型均表现在静纤毛顶连接及小根基部应力较高、固有频率近似.结论静纤毛在不与盖膜直接接触时更容易受兴奋性刺激.

关 键 词:盖膜  内毛细胞  静纤毛  有限元分析  豚鼠
收稿时间:2008-4-16
修稿时间:2008-6-12

Mechanical analysis of interaction between tectorial membrane and inner hair cell stereocilia
YANG Lin,DAI Pei-dong,HUA Cheng,ZHANG Tian-yu,DING Guang-hong,WANG Ke-qiang,WANG Zheng-min.Mechanical analysis of interaction between tectorial membrane and inner hair cell stereocilia[J].Acta Anatomica Sinica,2009,40(2):283-287.
Authors:YANG Lin  DAI Pei-dong  HUA Cheng  ZHANG Tian-yu  DING Guang-hong  WANG Ke-qiang  WANG Zheng-min
Institution:1. Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China; 2. Central Laboratory, Eye and ENT Hospital of Fudan University, Shanghai 200031,China;3. Institute of Cardiovascular Disease, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Abstract:Objective To investigate the interaction between tectorial membrane and inner hair cell stereocilia in the condition of vibration of the organ of Corti. Methods Two-2D finite-element models were built based on the electron microscopic images of the organ of Corti from the guinea pig with two models of coupled and non-coupled between the tectorial membrane and stereocilia. ANSYS software was used to analyze the two models. Results When Couette flow was loaded, the stereocilia had a larger angular displacement in non-coupled manner, Von Mises stress were higher on tip link and rootlet, and the characteristics of natural frequency were quite similar on two models.Conclusions The stereocilium is excited easily when it does not contact the tectorial membrane.
Keywords:Tectorial membrane  Inner hair cell  Stereocilia  Finite element analysis  Guinea pig
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