黏蛋白MUC-1在人胚胎胃黏膜发育中的阶段表达

目的 阐明MUC-1在胎儿胃黏膜的表达特点，探讨MUC-1与胃上皮分化的关系。方法 应用HE染色和SP免疫组织化学方法，检测22例9～30周胎儿胃黏膜的发育以及MUC-1在不同时期的表达。结果 胎儿胃黏膜的分化可分为3个不同时期：1．在未分化期MUC-1呈极性分布于早期胃上皮的游离面。2．在分化期MUC-1呈极性和弥漫性分布于中期胃黏膜上皮和腺上皮。3．生长期MUC-1分布于胃底腺上皮。结论 MUC-1的表达与胃上皮的分化密切相关。

MUC-1 EXPRESSION IN GASTRIC MUCOSA OF HUMAN FETUSES

Objective To explore the expression of MUC-1 (one mucin) in the gastric mucosa of human fetus at different developmental stages and elucidate the relationship between MUC-1 expression and the cytodifferentiation of gastric epithelia. Methods HE staining and immunohistochemistry methods were used. Results The differentiation of the fetal gastric epithelial cells could be divided into three stages, the undifferentiated (S1), the differentiating (S2), and the growing stages (S3). MUC-1 appeared in cell apex of all undifferentiated cells in S1. In S2, MUC-1 appeared in cell apex and cytoplasm in the differentiating cuboidal epithelial cells.In the S3, MUC-1 focused on the glands, especially in the basal cells of glands.Conclusion There was different expression of MUC-1 at various developmental stages of gastric epithelia.