胰岛淀粉样多肽在人胎胃的定位研究

目的 探讨胰岛淀粉样多肽(IAPP)在人胎胃的表达和定位。方法 免疫组织化学SABC法对12例11～20周人胎胃体部IAPP免疫反应(IR)细胞进行定位研究。结果 人胎11周，胃黏膜中已有IAPP-IR细胞，主要定位于胃底腺。14～20周，胃黏膜中IAPP-IR细胞数量逐渐增多，免疫反应显色也逐渐加深。经与HE染色的邻片比较，部分IAPP-IR细胞与壁细胞定位一致。结论 IAPP-IR细胞在人胎儿期已存在于胃体部。

LOCALIZATION STUDY OF ISLET AMYLOID POLYPEPTIDE IN THE STOMACH OF HUMAN FETUS

Objective To observe the expression and localization of the islet amyloid polypeptide(IAPP) in the stomach of human fetus. Methods The localization of IAPP immunoreactive(IR) cells in 12 human fetal bodies of stomach from 11th to 20th week of gestation was investigated with immunohistochemical SABC method. Results At 11th week of human fetal age,the IAPP-IR cells had been found in the gastric mucosa.The IAPP-IR cells were dominantly concentrated in the fundic gland.The number of IAPP-IR cells increased gradually,and the immunostain of immunoreactive cells darkened gradually from 14th to 20th week of gestation.As compared with the adjacent sections which were stained by HE,some IAPP-IR cells were co-localization with parietal cells.Conclusion IAPP-IR cells exist in the human fetal body of stomach..