The oncogenic impact of RNF2 on cell proliferation,invasion and migration through EMT on mammary carcinoma |
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| Authors: | Jin Wu Hao Wang Qing Li Qian-Ying Guo Si-Qi Tao Yu-Xian Shen Zheng-Sheng Wu |
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| Institution: | 1. Department of Pathology, Anhui Medical University, Hefei, Anhui, China;2. Institute of Biopharmaceuticals, School of Basic Medical Science, Anhui Medical University, Hefei, Anhui, China;3. Department of Pathology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, China |
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| Abstract: | Mammary carcinoma (MC) is one of most common malignancy in women, and ring finger protein 2 (RNF2) possesses various roles in vast human tumors. In MC tissues as well as in cell lines RNF2 exhibited high expression, had significant association with tumor size, lymph node status, TNM stage, patients’ poor survival, and promoted cell proliferation, colony formation, cell migration and invasion of MC cell lines which was mediated by downregulation of E-cadherin protein. These data reveal that RNF2 protein plays a vital role in the development of MC and may be a potential therapy target of MC. |
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| Keywords: | Corresponding author at: Department of Pathology Anhui Medical University Hefei Anhui 230601 China MC Mammary carcinoma RNF2 ring finger protein 2 miRNAs microRNAs IHC immunohistochemistry siRNA small interfering RNA RT-qPCR quantitative real-time polymerase chain reaction RFS relapse-free survival OS overall survival RNF2 Proliferation Migration Invasion E-cadherin Mammary carcinoma |
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