Anesthesia selectively reduces hypoglossal nerve activity by actions upon the brain stem |
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Authors: | Frederick M Bennett Walter M St John |
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Institution: | (1) Department of Physiology, Dartmouth Medical School, 03756 Hanover, NH, USA |
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Abstract: | Alcohol as well as anesthetic and sedative agents depress the respiratory activity of the hypoglossal-genioglossal system more than that of the phrenic-diaphragmatic system. The mechanisms for this selective depression remain unclear. To evaluate the contribution of pathways traversing the spinal cord, the response of phrenic and hypoglossal nerve activities to 0.5% halothane was obtained in decerebrate cats before and after transection of the spinal cord at T1 and again following transection at C1. Halothane produced a much greater decrease in hypoglossal than phrenic activity before and after spinal cord section at T1. Following cord section at C1, which eliminates phrenic activity, 0.5% halothane still priduced a marked depression of hypoglossal activity. Therefore, the selective depression of the hypoglossal-genioglossal system does not depend on spinal mechanisms and appears to be mediated in the brain stem. |
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Keywords: | autonomic ventilation halothane upper airway obstruction hypoglossus |
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