两种钛合金-骨界面的力学生物学研究

目的研究两种钛合金-骨界面的力学及生物学特性,从力学生物学的角度探讨不同钛合金-骨界面对骨细胞生物学行为的影响。方法通过建立钛合金内植物与骨相互作用的力学模型,分析材料属性变化对钛合金-骨界面力学性能变化的影响。通过动物体内实验,运用Micro-CT分析技术及组织切片观察不同钛合金-骨界面骨细胞生物学行为。结果钛合金-骨界面力学模型的理论推导和分析提示:TAV-骨界面的相对位移约是Ti2448-骨界面的相对位移的1.8倍。动物实验结果提示:Ti2448-骨界面周围骨质骨矿含量及骨质量均优于TAV-骨界面周围骨质。结论对于钛合金-骨界面而言,相对位移可能是力影响骨细胞功能的作用因素,较小的相对位移更有利于界面骨细胞的增殖,通过降低材料弹性模量,能够有效减低钛合金-骨界面相对位移,是实现钛合金-骨界面的更好愈合的可行方案。

Mechanobiological Studies about Two Kinds of Bone-Titanium Alloy interface

Objective To investigate the mechanobiological osteocyte biological behaviour for bone interface betweentwo kinds of titaniumalloy. Methods Mechanicalmodel was established by bolt and nut interaction under force, analysisof bone interface mechanical properties changes under different titanium alloys. Micro-CT analysis and tissue sectionshave been used for observing the osteocyte biological behavior around bone-titaniumalloy interface in experimental animals.Results In the bone-titaniumalloy interface mechanics model theory and analysis, compared to bone-Ti2448 interface,bone-TAVinterface relative displacement is approximately 1.8 times. The results of animal experiments suggestedthat the bone mineral content and bone quality are better around bone-Ti2448 interface than bone-TAV interface. ConclusionSmaller relative displacement is conducive to interface osteocyte proliferation in bone-titanium alloy interface.Reducing themodulus of elasticity ofmaterial is an effectivemethod, maybe, it is a possible option for the better interfacehealing.