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| 新型有序纳米介孔生物活性玻璃在模拟体液中的表面生物活性研究 | |
| 引用本文： | 陈建伟,张权,严晓霞,黄煌渊.新型有序纳米介孔生物活性玻璃在模拟体液中的表面生物活性研究[J].生物骨科材料与临床研究,2009,6(4):1-4. |
| 作者姓名： | 陈建伟 张权 严晓霞 黄煌渊 |
| 作者单位： | 1. 复旦大学附属华山医院骨科,上海,200040;上海交通大学医学院附属仁济医院骨科,上海200127 2. 复旦大学附属华山医院骨科,上海,200040 3. 复旦大学化学系无机材料合成实验室多孔材料课题组,上海,200433 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的评价新型行序纳米介孔生物活性玻璃（80SMBG）的体外生物活性及其对体液环境的影响。方法以Novabone为对照，利用模拟人体体液体外浸泡实验（SBF）的方法和扫描电镜（SEM）、等离子发射光谱仪（ICP）pH仪等技术，比较80SMBG与Novabone体外生成类似于天然骨中无机矿物的羟基磷灰石（HA）的能力，分析SBF中各离子浓度、pH值的变化情况。结果80SMBG在SBF中浸泡4h表面即有羟基磷灰石（HA）生成，浸泡1～4hSBF中Ca、P、Si的离子浓度迅速达到峰值，8h后逐渐降低直至稳定，pH仅在7．40～7．65范围内变化。结论80SMBG的体外生物活性更高，对体液微环境的影响更轻微，作为骨组织修复替代材料或骨组织工程支架材料具有较高的研究和应用价值。 |
| 关 键 词： | 生物活性玻璃 模拟人体溶液 体外 生物活性 |
The Study of the Mesoporous Bioactive Glass Biological Behavior in Stimulated Body Fluid |
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| Chen Jianwei, Zhang Quan Yan Xiaoxia,et al.The Study of the Mesoporous Bioactive Glass Biological Behavior in Stimulated Body Fluid[J].Orthopaedic Biomechanics Materials and Clinical Study,2009,6(4):1-4. | |
| Authors: | Chen Jianwei Zhang Quan Yan Xiaoxia |
| Institution: | Chen Jianwei1,2 Zhang Quan1* Yan Xiaoxia3,et al(.1)Department of Orthopedics,Huashan Hospital,Fudan University,Shanghai 200040,China,(2)Department of Orthopedics,Renji Hospital,Jiaotong University,Shanghai 200127,(3)Department of Chemistry,Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,Fudan Univer- sity,Shanghai 200433 |
| Abstract: | Objective To evaluate the bioactivity of mesoporous bioactive glass(80S MBG) and it's effect on the bio-logical environment in vitro. Methods The bioactivities of80S MBG and Novabone by soaking in Stimulated Body Fluid (SBF) was studied. SEM, ICP and pH Meter were employed to study the surface structure change, Ca、 P、 Si concentration change and pH change in SBE Results In SBF, it was found that HA took place at the surface of80S MBG after 4h, Ca, P, Si concentration rapidly reach the peak in 1～4h. And that pH change was very slight, from 7.40 to 7.65. Conclusion 80S MBG has higher bioactive in vitro and lower effect on SBF than Novabone. It may be used as bone-repaire and bone-substitute materials in the future. |
| Keywords: | Bioactive glass SBF In vitro Bioactivity |
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