可注射硫酸钙/羟基磷灰石复合物作为经皮椎体成形术填充物的实验研究

目的探讨椎体成形术的有效填充材料。方法采用PVP技术将40%可注射硫酸钙/羟基磷灰石(CSH/HA)复合物注入实验兔L6椎体内,L5椎体作为对照,于术后2、4、6、8、10、12周行影像学、组织学观察及骨组织计量学测定。结果影像学显示:术后4周实验椎体填充区密度明显高于周围松质骨密度,术后10～12周实验椎体填充区密度与周围松质骨一致。不脱钙骨组织学检查显示:术后4周复合物降解不明显,已出现成骨效应,6周实验椎体填充区内材料明显降解及出现新生骨小梁,8周实验椎体缺损边缘和中心部分的骨小梁逐渐成熟,10～12周椎体缺损已完全修复,为成熟的骨小梁组织所填充。骨组织计量学测定显示:术后10～12周实验椎体填充区骨小梁百分比及厚度与周围松质骨无显著差异。结论40%CSH/HA复合物在实验动物椎体内降解时间合适,成骨效应良好,新骨形成质量好,能有效修复椎体缺损,因而可能是一种理想的PVP填充物。

Experimental study on injectable calcium sulphate and hydroxy- apatite compounding as implant in Percutaneous Vertebroplasty

Objective To study the effective injectable implant for percutaneous vertebroplasty(PVP).Methods 40% Injectable calcium sulphate and hydroxyapatite compounding was injected into rabbit L6 vertebral bodies through PVP technique with L5 vertebral bodies as control.2,4,6,8,10,12 weeks after injection radiological and histological and bone histomorphometric examination were performed.Results Radiological examination showed that 4 weeks after injection density of injected area is higher than adjacent cancellous ...