Development of patient derived organoids for cancer drug screening applications期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Development of patient derived organoids for cancer drug screening applications

Institution:	1. Department of Biotechnology, Dr. M.G.R Educational and Research Institute, Deemed to be University, Chennai, Tamil nadu, India;2. Yale School of Medicine, Yale University, New Haven, CT, USA;3. Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil nadu, India;4. Department of Biochemistry, DKM College for Women, Vellore, Tamil nadu, India

Abstract:	Cancer is a disease characterised by abnormal cell growth that can invade or spread to other regions of the body. Organoids are three-dimensional ex vivo tissue cultures made from embryonic stem cells, induced pluripotent stem cells, progenitor cells or tissue that serve as a physiological model for cancer research. These are designed to recapitulate the in vivo properties of tumours. Importantly, effective recapitulation of the structure of tissues and function is believed to predict patient response, allowing for the creation of personalised therapy in a timely manner that may be used in the clinic. This Review discusses the pre-clinical model and different types of human organoids as models for the development of high throughput drug screening and also aims to highlight how organoids are shaping the future of cancer research.

Keywords:	Cancer Organoid Tissue Stem cell Progenitor cells Pre-clinical model HTS"} {"#name":"keyword" "$":{"id":"key0040"} "$$":[{"#name":"text" "_":"High Throughput Screening iPSCs"} {"#name":"keyword" "$":{"id":"key0050"} "$$":[{"#name":"text" "_":"induced pluripotent stem cells ESCs"} {"#name":"keyword" "$":{"id":"key0060"} "$$":[{"#name":"text" "_":"Embryonic stem cells PCs"} {"#name":"keyword" "$":{"id":"key0070"} "$$":[{"#name":"text" "_":"progenitor cells PDOs"} {"#name":"keyword" "$":{"id":"key0080"} "$$":[{"#name":"text" "_":"Patient-derived organoids ECM"} {"#name":"keyword" "$":{"id":"key0090"} "$$":[{"#name":"text" "_":"Extracellular matrix PDTX"} {"#name":"keyword" "$":{"id":"key0100"} "$$":[{"#name":"text" "_":"Patient-derived xenografts CNS"} {"#name":"keyword" "$":{"id":"key0110"} "$$":[{"#name":"text" "_":"Central nervous system GLICO"} {"#name":"keyword" "$":{"id":"key0120"} "$$":[{"#name":"text" "_":"Glioma cerebral organoid EphB3"} {"#name":"keyword" "$":{"id":"key0130"} "$$":[{"#name":"text" "_":"Ephrin type-B receptor 3 SCLC"} {"#name":"keyword" "$":{"id":"key0140"} "$$":[{"#name":"text" "_":"small-cell lung cancer NSCLC"} {"#name":"keyword" "$":{"id":"key0150"} "$$":[{"#name":"text" "_":"Non-small lung cancer MBM"} {"#name":"keyword" "$":{"id":"key0160"} "$$":[{"#name":"text" "_":"Minimum basal medium LV"} {"#name":"keyword" "$":{"id":"key0170"} "$$":[{"#name":"text" "_":"Leucovorin MTX"} {"#name":"keyword" "$":{"id":"key0180"} "$$":[{"#name":"text" "_":"Methotrexate OC"} {"#name":"keyword" "$":{"id":"key0190"} "$$":[{"#name":"text" "_":"Ovarian cancer PDAC"} {"#name":"keyword" "$":{"id":"key0200"} "$$":[{"#name":"text" "_":"Pancreatic ductal adenocarcinoma
本文献已被 ScienceDirect 等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏