流体剪切力在骨生长、重建中的重要作用

骨组织具有最优化结构,是一个典型的结构-功能受生物力学控制的例子。力学因素在骨的生长、重建和成形中起着十分重要的作用,但力学刺激的本质形式至今无法确认。骨组织存在多孔结构,力学负荷引起的变形会促使流体流动对骨细胞产生作用,离体实验也证实骨细胞能对流体产生响应,因此流体剪切力是研究骨组织受力学调控时考虑的一个重要方面。现有的研究主要体现在流体的有效作用形式,细胞的生物学反应,以及流体剪切力在细胞中的力学转导;各个方面的研究都提示,流体剪切力至少部分的参与了骨组织内的力转导。作者就这方面的研究进展作一综述。

Concept review: resultful effects of fluid flow on bone growth and remodeling

Objective Bone tissue has a optimal structure, which could present a typical example to show how the structure-function of bone controlled by biomechanics The mechanics plays an important role in the growing, reconstructing and shaping of bone. But up to now it has not been able to essentially illustrate this mechanic stimulation The bone tissue is a kind of porous struction and its deformation resulted from mechanic loading can cause fluid flow to make the effect on bone cells, which also has been proved by the vitro experiments. So the flow shear stress is one of the important factors when study bone tissue controlled by mechanic loaded, The present study on the flow shear stress mainly shows the effective function of theflows, the bio-reaction of cells and the mechanic transmission researched by the flow shear stress in cells.Many of these studies indicated that at least in part fluid shear stress is concerned with the mechanotransduction in bone tissue