力学因素在间充质干细胞构建功能性组织工程化软骨中的作用

间充质干细胞具有多向分化潜能,可定向分化为软骨组织,并且取材广泛、体外扩增能力强,是广泛应用于软骨组织工程的理想细胞之一。由于关节软骨具有重要的生物力学功能,需要强调和评估间充质干细胞构建组织工程化软骨组织的力学生物学性能。为更好地了解和认识修复软骨的诱导因素、信号通路与力学特性之间的关系,本文回顾了间充质干细胞在功能性软骨组织工程研究中的力学生物学研究进展,并论述了该领域内目前存在的问题及若干可供探索的途径和新方向。

Role of mechanobiology in mesenchymal stem cell-based tissue engineered cartilage

Mesenchymal stem cells (MSCs) is an ideal cell type extensively used in cartilage multipotency to differentiate into cartilage and can be isolated from a wide variety of tissue sources with strong in vitro expansion. Since cartilage has the important mechanical properties, it is necessary to highlight and evaluate the mechanobiological properties of MSC-based tissue engineered cartilage. To better understand the relationship between inducing factor of cartilage repair, signal pathway and mechanical properties, this paper reviews the advances made on research of mechanobiology in MSC-based tissue engineering cartilage, discusses the existing problems in this field, and try to point out some new approaches or directions worthy of such investigation.