骨质疏松对骨的粘弹性性质影响的实验研究

目的研究正常大鼠股骨和维甲酸所致大鼠骨质疏松股骨的压缩粘弹性性质,为临床提供生物粘弹性力学参数。方法选用175～245g,6月龄Wistar大鼠30只,随机分为正常对照组15只,模型组15只。对模型组大鼠每日灌服维甲酸(70mg·kg-1·d-1),实验动物于第12周末处死。取股骨进行压缩应力松弛、蠕变实验。结果得出了正常对照组和模型组股骨应力松弛,蠕变数据和曲线。对应力松弛蠕变实验数据进行归一化处理,得出归一化应力松弛函数、蠕变函数及曲线。结论模型组的7200s应力松弛、蠕变量指标显著低于正常对照组(P<0.05)。

Experiment study on bone biscoelasticity properties impact of osteoporosis

Objectives Research on the compression viscoelasticity property of normal white rat and the osteoporosis femoral compression viscoelasticity property caused by alltransretinois acid to provide bioviscoelastic mechanics parameters for clinic. Methods Choose 30 Wistar white rats of 6-month old with 175-245gand randomly divided into 2 groups with 15 as normal group and 15 as model group alltransretinois acid was given (70mg·kg-1·d-1) to the model group two weeks. At the end of Week 12, execute the model rats to take the femora for telescope, stress relaxation, creep experiments. Results The femora stress relaxation,creep data and the curves of both the normal and model groups were received. The normalization for the stress relaxation and crept experimental data were made to get their functions and the curve. Conclusions The 7200s stress relaxation and the amount of creep indices in the model set were much lower than that of the normal group (P<0.05).