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糖皮质激素对大鼠股骨及腰椎的生物力学影响
引用本文:廖进民,李青南,胡彬,吴铁,黄连芳,李朝阳,赵卫东,朱青安.糖皮质激素对大鼠股骨及腰椎的生物力学影响[J].医用生物力学,1999,14(4):222-225.
作者姓名:廖进民  李青南  胡彬  吴铁  黄连芳  李朝阳  赵卫东  朱青安
作者单位:广东医学院骨生物学研究室;广东医学院骨生物学研究室;广东医学院骨生物学研究室;广东医学院骨生物学研究室;广东医学院骨生物学研究室;广东医学院骨生物学研究室;广东医学院骨生物学研究室;广东医学院骨生物学研究室
基金项目:广东省中医药管理局资助
摘    要:目的:从生物力学角度研究GC对大鼠皮质和松质骨的影响。方法:采用3月龄♂SD大鼠19只,随机分为基础对照组、年龄对照组和激素模型组后者灌喂醋酸泼尼松4.5mg/kg,2次/周。3个月后取股骨和第3~5腰椎行股骨干的扭转、三点弯曲和腰椎的压缩试验。结果:激素模型组与年龄对照组比较,股骨干在三点弯曲试验时所随的载荷减少了17.1%(P〈0.05),无椎弓的椎体压缩试验时所随的载荷减少了29.9%(P〉

关 键 词:骨质疏松  股骨  腰椎  生物力学  糖皮质激素

BIOMECHANICAL EFFECTS OF GLUCOCORTICOIDS ON FEMUR AND LUMBER VERTEBRAE IN RATS
Liao Jinmin,Li Qingnan,Hu Bin, et al.BIOMECHANICAL EFFECTS OF GLUCOCORTICOIDS ON FEMUR AND LUMBER VERTEBRAE IN RATS[J].Journal of Medical Biomechanics,1999,14(4):222-225.
Authors:Liao Jinmin  Li Qingnan  Hu Bin  
Abstract:To evaluate the effects of glucocorticoids(GC) on conical bone and cancellous bone inrats with biomechanical way. Methods: Nineteen male Sprague-Dawley rats were randomly dividedinto Basal, Aging and Hormone group, the latter was given prednisone acetate (4.5mg/kg) twice aweek. The torsion, three-point bending and compression tests were respectively made on femurs and3ird--5th lumbar vertebrae of three groups after 3 months. Results: In GC group, the loads imposedon the femoral middle segments in three-point bending and on the lumbar vertebral(no-vertebralarch) in compression tests were separately decreased by 17.1 %(p<0.05) and 29.9%(p<0.05) thoughthe rest parameters tended to decrease, compared with the control group. Conclusions When GCused for a long time, the biomechanical characters of conical and cancellous bone in the rats wouldbe led to decrease and bone fracture be prone to occur.
Keywords:prednisone  osteoporosis  femur  lumbar vertebrae  biomechanics
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