心血管生物力学研究的新进展

心血管生物力学研究领域最重要的新进展有两个方面:一是心血管力学生物学研究。阐明力学因素如何产生生物学效应而导致血管重建,研究心血管信号转导通路和力学调控途径,从细胞分子水平深入了解心血管活动和疾病发生的本质;二是以临床影像为基础的心血管生物力学建模与个体化手术设计研究。应用流体力学理论,结合医学影像和先进的流场测试技术,进行心血管建模与定量分析,研究心血管功能新的无创检测技术和个体化治疗体系设计,为心血管病的诊断、治疗和预警提供生物力学的解决方案。本期心血管生物力学专刊发表了7篇国内同行的相关研究论文。这些论文的内容涵盖了血管壁细胞力学生物学和紧密结合临床的心血管生物力学建模研究,反映了我国心血管生物力学研究的一些新进展。

Recent advances in cardiovascular biomechanics

There are two important recent advances in cardiovascular biomechanics. One is cardiovascular mechanobiology, which illustrates how mechanical factors can generate biological effects resulting in vascular remodeling. By studying signal transduction pathway in the cardiovascular system and means of mechanical control, cardiovascular mechanobiology aims to investigate the nature of cardiovascular disease at cellular and molecular level. The other is cardiovascular numerical simulation and individual design of surgery operation on the basis of clinical images. Based on fluid mechanics, clinical images as well as advanced measuring and testing methods of flow field, cardiovascular numerical simulation and quantitative analysis can be conducted. New in vivo techniques for studying cardiovascular function and the design of individual surgery system can provide biomechanical solutions for the diagnosis, therapy and prewarning of cardiovascular disease. In this special issue, seven papers on cardiovascular biomechanics are published, covering vascular cell mechanobiology and cardiovascular numerical simulation connected with the clinical problems tightly. These papers show us some recent advances in cardiovascular biomechanics in China.