| 抗血管生成因子Angiostatin与Endostatin作用下肿瘤血管生成的二维数值模拟 |
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| 引用本文： | 赵改平,高昊,吴洁,许世雄,Collins MW,Carola Koenig,Padhani AR.抗血管生成因子Angiostatin与Endostatin作用下肿瘤血管生成的二维数值模拟[J].医用生物力学,2006,21(4):272-279. |
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| 作者姓名： | 赵改平 高昊 吴洁 许世雄 Collins MW Carola Koenig Padhani AR |
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| 作者单位： | 复旦大学力学与工程科学系;复旦大学力学与工程科学系;复旦大学力学与工程科学系;复旦大学力学与工程科学系;Brunel Institute for Bioengineering School of Engineering and Design Brunel University;Brunel Institute for Bioengineering; School of Engineering and Design; Brunel University;Paul Strickland Scanner Centre; Mount Vernon Hospital |
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| 基金项目： | 国家自然科学基金(10372026) |
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| 摘 要： | 目的数值模拟抗血管生成因子Angiostatin和Endostatin对肿瘤血管生成的影响。方法建立肿瘤内外血管生成的二维离散数学模型。模型耦合两种抗血管生成因子Angiostatin和Endostatin的抑制效应,数值模拟在促血管生成因子诱导下肿瘤微血管网生成,讨论血管生成抑制因子的影响。结果抗血管生成因子Angiostatin对肿瘤内外血管网络生成的速度和成熟度有抑制作用。抗血管生成因子Angiostatin和Endostatin耦合作用时,在肿瘤血管生成的早期有明显的抑制效应;在肿瘤血管生成的中后期,它们可以降低肿瘤血管化程度。结论本文模型能够较好的模拟抗血管生成因子Angiostatin和Endostatin对内皮细胞迁移和增殖的抑制作用。
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| 关 键 词： | 抗血管生成因子 Angiostatin Endostatin 肿瘤血管生成 数学模型 |
| 文章编号： | 1004-7220（2006）04-0272-08 |
| 收稿时间： | 2006-09-18 |
| 修稿时间： | 2006-09-182006-10-22 |
2D numerical simulation of effect of antiangiogenic factors Angiostatin and Endostatin on tumor-induced angiogenesis |
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| ZHAO Gai-ping, GAO Hao, WU Jie, XU Shi-xiong, Collins MW, LONG Quan, Carola Koenig, Padhani AR..2D numerical simulation of effect of antiangiogenic factors Angiostatin and Endostatin on tumor-induced angiogenesis[J].Journal of Medical Biomechanics,2006,21(4):272-279. |
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| Authors: | ZHAO Gai-ping GAO Hao WU Jie XU Shi-xiong Collins MW LONG Quan Carola Koenig Padhani AR |
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| Institution: | 1. Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China; 2. Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK;3. Paul Strickland Scanner Centre, Mount Vernon Hospital, Middlesex HA6 2RN, UK |
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| Abstract: | |
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| Keywords: | Anti-angiogenesis Angiostatin Endostatin Tumor-induced angiogenesis Mathematical model |
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