Molecular characterization of three novel murine noroviruses |
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Authors: | Charlie C Hsu Lela K Riley Robert S Livingston |
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Institution: | (1) Research Animal Diagnostic Laboratory, Department of Veterinary Pathobiology, University of Missouri, 1600 East Rollins Road, Columbia, MO 65211, USA |
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Abstract: | Murine noroviruses (MNV) comprise a group of newly recognized pathogens infecting laboratory mice. The first reported murine
norovirus, murine norovirus 1 (MNV-1), produces a transient infection with a short duration of fecal shedding after infection
of immunocompetent laboratory mice. Our laboratory subsequently isolated three novel murine noroviruses, murine norovirus
2 (MNV-2), murine norovirus 3 (MNV-3), and murine norovirus 4 (MNV-4), that have markedly different pathogenicity from MNV-1
by producing persistent infections and prolonged fecal shedding in infected immunocompetent mice. In this study, the nucleotide
sequences and the predicted amino acid sequences of the three novel murine noroviruses were determined and compared to each
other, MNV-1, and other previously described human and animal noroviruses. The three novel murine norovirus strains were shown
to be related to each other and MNV-1 by sequence and phylogenetic analysis even though MNV-2, MNV-3 and MNV-4 all display
markedly different biologic behavior from that of MNV-1.
The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have
been assigned the accession numbers DQ223041, DQ223042, and DQ223043. |
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Keywords: | Murine Norovirus MNV Phylogenetic analysis Sequence analysis Pathogenicity |
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