围产期女性不同时点抑郁症状检出率及影响因素

目的:了解妇女在围产期不同时点的抑郁症状检出率及其影响因素。方法:2016年9月到2017年2月,在两家妇幼保健院进行产检的508名妇女中完成了全部时点的随访(从孕早期至产后6周,随访7次),使用爱丁堡产后抑郁量表(EPDS)进行抑郁筛查,计算所有时点的抑郁症状检出率,同时在各个时点测量抑郁影响因素。结果:7次随访的抑郁症状检出率为24.8%~37.6%;产后两个时点的中重度抑郁症状检出率均高于轻度抑郁症状(13.0%~14.3%vs.11.8%~13.0%,均P<0.05)。孕早期抑郁症状(OR=2.54、2.05)和产后焦虑(OR=1.43、1.13)与产后1周及产后6周的抑郁症状均正向关联;孕早期焦虑与孕12周至40周共5个时点的抑郁症状正向关联(OR=7.27、1.28、1.18、1.18、1.18)。结论:围产期不同时点的抑郁症状检出率不同,焦虑在整个围产期都与抑郁持续相关。

Point detection rates of depression symptoms and related factors in perinatal women

Objective:To investigate the point detection rates of perinatal depressive symptoms and related factors.Methods:From September 2016 to February 2017,508 women were followed up and investigated from early pregnancy to 6 weeks postpartum at 7 time points across the whole perinatal period.Perinatal depression was measured with the Edinburgh Postnatal Depression Scale(EPDS).Possible related factors of depressive symptoms were measuredatdifferenttimepoints.Results:The detection rates of perinatal depressive symptoms were 24.8%-37.6%.The detection rates of moderate to severe depressive symptoms in postpartum period were higher than those of minor depressive symptoms(13.0%-14.3% vs.11.8%-13.0%,Ps<0.05).The depressive symptoms at early pregnancy(OR=2.54,2.05)and postpartum anxiety(OR=1.43,1.13) were positively associated with postpartum depressive symptoms in one-and six-week postpartum.The anxiety during early pregnancy was positively associated with antenatal depressive symptoms at 5 time points from 12 to 40 gestational weeks(OR=7.27,1.28,1.18,1.18,1.18).Conclusion:The detection rate of depression symptoms may be different at different time points of perinatal period.Anxiety was consistently related to depression in the whole perinatal period.