Application of catheter-tip i.s.f.e.t. for continuousin vivo measurement |
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Authors: | K Shimada M Yano K Shibatani Y Komoto M Esashi T Matsuo |
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Institution: | (1) Central Research Laboratories, Kuraray Co. Ltd., Aoeyama Sakazu, 710 Kurashiki, Okayama, Japan;(2) Department of Surgery, Institute of Thermal Spring Research, Okayama University, Yamada, Misasa, Tottori, Japan;(3) Department of Electric Engineering Tohoku University, Aoba, Aramaki-aza, 980 Sendai Miyagi, Japan |
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Abstract: | A catheter-tip pH sensor was developed for possible clinical and biomedical application, using an ion-sensitive field-effect
transistor (i.s.f.e.t.). Its signal drift in buffer solutions during continuous measurement was less than 3 mV in 24 h (equivalent
to about 0·05 pH in 24 h). The electric insulation was perfect when soaked in buffer solutions for more than 3 months. A continuousin vivo pH measurement was successfully achieved in nonheparinised arterial blood of a japanese monkey. There was no significant
sign of clot formation for 8 hours. It revealed quick responses to respiratory acidosis and alkalosis, and the observed pH
values were in accordance with those confirmed by a blood pH analyser. Also, a catheter-tip pCO2 sensor was prepared, using the catheter-tip pH i.s.f.e.t. The response time was 2 min for a 90% change in CO2 tension. The muscle pCO2 monitoring tested with it indicated a similar result to those with medical mass spectrometer. |
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Keywords: | Blood monitoring Catheter-tip pH sensor I S F E T Miniature pH sensor Miniature pCO2 sensor |
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