CSF-1R和VEGF在人声门上型喉癌的表达及与淋巴结转移的关系

目的研究巨噬细胞集落刺激因子受体(macrophage colony-stimulating factor receptor,CSF-1R)和血管内皮生长因子(vascular endothelial factor,VEGF)在声门上型喉鳞状细胞癌的表达及其与喉癌淋巴结转移之间的关系。方法应用免疫组化方法对30例无淋巴结转移的声门上型喉癌组织标本,15例有淋巴结转移的声门上型喉癌组织标本及10例正常喉组织粘膜标本中CSF-1R和VEGF的蛋白表达进行检测,并对其与喉癌相关的临床病理参数进行统计学分析。结果 CSF-1R和VEGF在声门上型喉鳞癌组织中呈强阳性表达,表达水平显著高于对照组(P<0.05),其中有淋巴结转移组明显高于无淋巴结转移组(P<0.05)。结论 CSF-1R和VEGF在声门上型喉癌过表达与淋巴结转移呈正相关。

The expression of CSF-1R and VEGF and their relationship with lymphoid metastasis in human supraglottic laryngeal squamous carcinoma

Objective To investigate the expression of macrophage colony-stimulating factor receptor (CSF-1R) and vascular endothelial factor (VEGF)and their relationship with lymphoid metastasis in human supraglottic laryngeal squamous carcinoma. Methods The expression of CSF-1R and VEGF was detected by S-P immunohistochemistry in 10 cases of laryngeal adjacent normal tissue,30 cases of supraglottic laryngeal carcinoma tissue without metastatic cervical lymph node and 15 cases of supraglottic laryngeal carcinoma with metastatic cervical lymph node tissue. Results The difference of CSF-1R and VEGF expression between supraglottic laryngeal carcinoma versus normal tissues was statistically significant (P<0.05); With significant correlation between CSF-1R and VEGF expression in the supraglottic laryngeal carcinoma (P<0.05). The positive rates of CSF-1R and VEGF expression were higher in lymphoid metastasis carcinoma than in no-lymphoid metastasis carcinoma (P<0.05). Conclusion CSF-1R and VEGF may play an important role in carcinogenesis, invasion and lymphoid metastasis in supraglottic laryngeal carcinoma, expression of them might be served as an objective indicator for predicting occurrence of cancer cell lymphoid metastasis.