胰岛素样生长因子—Ⅰ在胎儿肝，肾等组织的分布

目的 研究胰岛素样生长因子（IGFs）对胎儿组织增殖和分化的作用。方法 应用免疫组化ABC法对16至24周胎龄肝、肾、肾上腺、脾、胸腺等ICF－I阳性细胞进行定位研究。结果 胎儿期内，以上器官中均有IGF－I阳性细胞存在，不同个体和器官其阳性细胞的数量、反应强弱和表达情况有差异。结论 在人胎发育过程中，这些器官组织均能表达IGF－I，对其增殖分化起着自分泌和旁分泌的作用。

Immunohistochemical Study of Insulin-Like Growth Factor-I in Human Fetal Organs

Objective　To study the distribution of insulin-like Growth Factors (IGFs) in liver、 spleen、kidney、thymus and supraadrenal glands of fetus from 16 to 24 weeks.Method　Using ABC immunohistochemistry. Results　 IGF-I positive cells were found in these organs during this period of fetal life, but the differences of number and reaction intensity of IGF-I positive cells appeared in different organs and individuals.Conclusion　These organs tissues can express IGF-I during fetal development and play paracrine and/or autocrine role in cellular proliferation and differentiation of these fetal tissue.