| KLFs与肿瘤发生发展的关系 |
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| 引用本文： | 郑乐,李天人,郭科军.KLFs与肿瘤发生发展的关系[J].解剖科学进展,2014(6):585-587. |
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| 作者姓名： | 郑乐 李天人 郭科军 |
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| 作者单位： | 中国医科大学附属第一医院妇科,辽宁沈阳110001 |
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| 基金项目： | 沈阳市科技计划项目（F11-262-9-14） |
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| 摘 要： | Krüpple是果蝇分节基因"间隙基因"类的一个成员,它编码一个包含一个DNA结合序列的蛋白质,该序列由几个Cys2/His2型的锌指构成,一群与Krüpple的锌指结构高度同源的蛋白质被发现,命名为Krüpple样因子(Krüpple-like factor,KLFs),它们通过调控多种富含GC或CACCC的启动子的基因的表达,参与细胞增殖、分化、凋亡和肿瘤发生、发展等多种生理、病理过程。本文综述KLFs的结构、表达调控功能、主要家族成员及其在肿瘤研究中的现状,探讨其与肿瘤发生发展的关系。
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| 关 键 词： | KLFs 分节基因 锌指结构 细胞增殖 结合序列 高度同源 启动子 Smad 宫颈鳞癌 结构域 |
The relationship of KLFs with occurrence and development of tumor |
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| ZHENG Le,LI Tian-ren,GUO Ke-jun.The relationship of KLFs with occurrence and development of tumor[J].Progress of Anatomical Sciences,2014(6):585-587. |
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| Authors: | ZHENG Le LI Tian-ren GUO Ke-jun |
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| Institution: | ( Department of Gynecology, the First Affiliated Hospital, China Medical University, Shenyang 110001, China ) |
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| Abstract: | Krtipple is a member of the ＂gap gene＂, flies segmentation gene, encoding a DNA binding sequence protein, the sequence is composed of several Cys2 / His2 type zinc finger. A group of highly homologous proteins with zinc finger structure of Krtipple were named as Krtipple sample factor （Krfipple-like factor, KLFs）. They are involved in cell proliferation, differentiation, apoptosis and tumor occurrence, development and a variety of physiological and pathological process through regulating the expressions of rich containing GC or CACCC promoter genes. This review explores its relationship with the occurrence and development of tumor. |
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| 本文献已被 CNKI 维普 等数据库收录！ |
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