Bioreactions at the tissue/hydroxyapatite interface |
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| Authors: | CA van Blitterswijk JJ Grote W Kuÿpers CJG Blok-van Hoek WTh Daems |
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| Institution: | 1. Department of Otorhinolaryngology, University Hospital, Leiden, The Netherlands;2. ENT Research Laboratory, Radboud Hospital, Nijmegen, The Netherlands;3. Laboratory for Electron Microscopy, University of Leiden, The Netherlands |
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| Abstract: | The events at the hydroxyapatite implant material/tissue interface in the rat middle ear were studied by light microscopy, autoradiography, morphometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray microanalysis. Deposition of calcium, partially in the form of calcium phosphate, was found at the interface. Resorption of the implant material occurred as the result of mono- and multinuclear phagocyte activity. Resorption decreased 6 mnth after the operation, possibly due to the decreasing number of phagocytes at the interface and the increasing amount of bone in the macropores. |
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| Keywords: | Biodegradability hydroxyapatite interface phagocyte calcium tympanoplasty |
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