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Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies |
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| Authors: | Akbil Bengisu Meyer Tim Stubbemann Paula Thibeault Charlotte Staudacher Olga Niemeyer Daniela Jansen Jenny Mühlemann Barbara Doehn Jan Tabeling Christoph Nusshag Christian Hirzel Cédric Sanchez David Sökler Nieters Alexandra Lother Achim Duerschmied Daniel Schallner Nils Lieberum Jan Nikolaus August Dietrich Rieg Siegbert Falcone Valeria Hengel Hartmut Kölsch Uwe Unterwalder Nadine Hübner Ralf-Harto Jones Terry C Suttorp Norbert Drosten Christian Warnatz Klaus Spinetti Thibaud Schefold Joerg C Dörner Thomas Sander Leif Erik Corman Victor M Merle Uta Kurth Florian von Bernuth Horst Meisel Christian Goffinet Christine |
| Institution: | 1.Institute of Virology, Charité – Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin and Humboldt-Universit?t Zu Berlin, Charitéplatz 1, 10117, Berlin, Germany ;2.Berlin Institute of Health at Charité - Universit?tsmedizin Berlin, Berlin, Germany ;3.Labor Berlin GmbH, Department of Immunology, Charité - Universit?tsmedizin Berlin, Sylter Str. 2, 13353, Berlin, Germany ;4.Department of Infectious Diseases and Respiratory Medicine, Charité-Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin and Humboldt-Universit?t Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany ;5.Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t Zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany ;6.DZIF German Centre for Infection Research (DZIF), Partner Site Charité, 10117, Berlin, Germany ;7.Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany ;8.Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland ;9.Department of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ;10.Center for Chronic Immunodeficiency (CCI), Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ;11.University Medical Center Freiburg and Faculty of Medicine, University of Freiburg, Center for Biobanking, FREEZE-Biobank, Freiburg, Germany ;12.Cardiology and Medical Intensive Care, Heart Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany ;13.Department of Anesthesiology and Critical Care, Medical Center - University of Freiburg, Freiburg, Germany ;14.Faculty of Medicine, University of Freiburg, Freiburg, Germany ;15.Division of Infectious Diseases, Department of Medicine II, Medical Centre – University of Freiburg, Faculty of Medicine, University of Freiburg, 79106, Freiburg, Germany ;16.Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany ;17.Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing St, Cambridge, CB2 3EJ, UK ;18.Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, CH-3010, Bern, Switzerland ;19.Department of Medicine/Rheumatology and Clinical Immunology, Charité-Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin and Humboldt-Universit?t Zu Berlin, Berlin, Germany ;20.DRFZ, Berlin, Germany ;21.Labor Berlin GmbH, Berlin, Germany ;22.Department of Gastroenterology, Heidelberg University Hospital, Heidelberg, Germany ;23.Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and Department of Medicine I, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany ;24.Charité - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t Zu Berlin, and Berlin Institute of Health (BIH), Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany ;25.Institute of Medical Immunology, Charité – Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin and Humboldt-Universit?t Zu Berlin, Berlin, Germany ; |
| Abstract: | Journal of Clinical Immunology - Six to 19% of critically ill COVID-19 patients display circulating auto-antibodies against type I interferons (IFN-AABs). Here, we establish a clinically applicable... |
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